Mesna Powder Mixing Device for Stable Surgical Dissection

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Solution Overview

Problem

Current Mesna solutions in liquid form are unstable due to oxidation, require cumbersome handling, and lack concentration flexibility, leading to reduced efficacy and increased health risks and costs in surgical tissue separation procedures.

Innovation Solution

A device with separate chambers for Mesna powder and sterile physiological saline solution, allowing immediate mixing and delivery of Mesna solution at desired concentrations, eliminating the need for stabilizing agents and reducing oxidation risks, while enabling controlled and isotonic delivery during surgery.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If Mesna is stored in liquid form in glass containers, then it requires stabilizers and anti-oxidants to prevent oxidation, but this increases contamination risk, surgery time, and patient health risks

Engineering Contradiction:

Improvestability of Mesna solutionVSAvoidcontamination risk and patient health risks

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent replaces the need for stabilizers and anti-oxidants by storing Mesna in an inert environment (lyophilized powder form) that prevents oxidation, eliminating harmful additives from the final solution

Inventive Principle:

Principle #39Inert atmosphere (Inert environment)

Solution Approach 2:

The patent extracts and removes the harmful stabilizers and anti-oxidants from the Mesna solution by using lyophilized powder that dissolves in sterile water to create a stabilizer-free solution

Inventive Principle:

Principle #2Taking out (Extraction)

2Stability of the object's composition

If commercial Mesna solutions are used, then they are stabilized with pH adjustment agents and additives, but this increases cost and presents health risks to patients

Engineering Contradiction:

Improvestability of Mesna solutionVSAvoidhealth risks from additives

Core Design Contradiction:

Stability of the object's compositionVSObject-generated harmful factors

Solution Approach 1:

The patent changes the physical state parameter of Mesna from liquid to lyophilized powder, and adjusts the concentration parameter to provide flexible dosing options ranging from 5% to 50% Mesna in sterile water

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent eliminates harmful additives by using lyophilized powder stored in an inert state that dissolves in sterile water to create a pure Mesna solution without pH adjustment agents or stabilizers

Inventive Principle:

Principle #39Inert atmosphere (Inert environment)

3Ease of operation

If Mesna solution is transferred from glass containers to delivery devices, then it increases contamination risk and surgery time, but this is necessary for delivery to target tissue

Engineering Contradiction:

Improvehandling convenience of MesnaVSAvoidsurgery time

Core Design Contradiction:

Ease of operationVSLoss of time

Solution Approach 1:

The patent merges the storage and delivery functions into a single integrated device where lyophilized Mesna powder is stored in a cartridge that connects directly to a syringe containing sterile water, eliminating the need for separate transfer steps

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

The patent performs preliminary preparation by pre-packaging lyophilized Mesna powder in sterile cartridges and pre-filling syringes with sterile water before surgery, so that only a simple connection and mixing step is needed during the procedure

Inventive Principle:

Principle #10Preliminary action

4Adaptability or versatility

If commercial Mesna vials are used, then concentration is fixed and practitioner can only dilute, but this limits flexibility when higher concentrations are needed

Engineering Contradiction:

Improveconcentration flexibility of MesnaVSAvoidcomplexity of concentration adjustment

Core Design Contradiction:

Adaptability or versatilityVSDevice complexity

Solution Approach 1:

The patent provides concentration flexibility by offering cartridges with different Mesna powder concentrations (5%, 10%, 20%, 30%, 40%, 50%) and allowing practitioners to adjust the volume of sterile water added to achieve the desired final concentration

Inventive Principle:

Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The device stabilizes Mesna, reduces surgical time, minimizes tissue damage, and lowers costs by providing a flexible concentration option, enhancing surgical precision and safety with immediate and controlled delivery of Mesna solution.

Implementation Method 1

a first chamber for housing the solute, a second chamber for housing the solvent... and are in fluid communication with each other upon disruption of said separation means thereby forming the solution

Methodology Applied

Scientific EffectDissolution: Solvation

Data Source

PatentEP2994062B1Device for chemically assisted dissection

Publication Date: 2019.10.02 AUXIN SURGERY SA

Figure 1A
Figure 1B~1C
Figure 1D

AI summary

The invention provides a device for delivering a solution to tissues and/or organs, the solution comprising at least one solvent and at least one solute. The device comprises at least one chamber (8) which comprises sodium 2-mercaptoethanesulfonate in powder form. A method comprising the steps of dissolving the solute in the solvent inside the device thereby obtaining the solution, and delivering immediately the obtained solution to said tissues and/or organs to facilitate dissection is described.