Mesocellular Oxide Foam Hemostasis Without Heat Generation
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Solution Overview
Problem
Current hemostatic compositions for severe bleeding wounds, particularly in remote or battlefield settings, require improvement in rapidity and safety of blood clotting initiation, with existing methods sometimes causing adverse side effects due to heat generation and requiring intensive training or equipment for application.
Innovation Solution
Development of a hemostatic composition comprising a mesocellular oxide foam with an average pore size of 10-100 nm, optionally loaded with a biologically active agent like thrombin, which can be applied directly to wounds to promote rapid and effective blood clotting without the need for extensive training or equipment.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Speed
If dry bound zeolite is used for hemostasis, then rapid blood clotting is achieved, but heat generation causes adverse side effects
Solution Approach 1:
The patent employs a porous alumina matrix with controlled pore structure to replace dry bound zeolite. The porous structure provides high surface area for blood contact and clotting factor activation while the alumina material itself does not generate harmful heat during the hemostatic process, thus resolving the contradiction between rapid clotting and heat generation
Solution Approach 2:
The patent changes the material parameter from zeolite to alumina, and controls the pore size parameter (10-100 nm) to optimize both clotting speed and thermal properties. This parameter change allows the material to achieve rapid hemostasis without the adverse heat generation effect of zeolite
2Reliability
If complex hemostatic equipment is used, then effective blood clotting is achieved, but intensive training and equipment are required
Solution Approach 1:
The hemostatic composition is designed to function automatically upon contact with blood. The porous alumina structure naturally activates clotting factors and the material self-regulates the hemostatic process without requiring complex equipment or intensive training, making it easy to apply while maintaining high effectiveness
Solution Approach 2:
The patent extracts the complex equipment requirements from the hemostatic system and replaces them with a simple, standalone hemostatic composition that can be applied directly to wounds without auxiliary devices or complex application procedures
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The mesocellular oxide foam composition initiates blood clotting more quickly and effectively than existing methods, reducing the risk of adverse side effects and enabling rapid stabilization of wounds in emergency situations, even in resource-limited environments.
Implementation Method 1
contacting a mesocellular oxide foam... with a solution containing a biologically active agent, said contacting being for a time sufficient to provide for adsorption or absorption of the biologically active agent to the mesocellular foam
Implementation Method 2
contacting a mesocellular oxide foam... with a solution containing a biologically active agent, said contacting being for a time sufficient to provide for adsorption or absorption of the biologically active agent to the mesocellular foam
Data Source
AI summary
The present invention relates to hemostatic compositions comprising a mesocellular oxide foam and, optionally, a biologically active agent such as a procoagulant, as well as devices and methods of use to promote blood clotting.