Mesoionic Insecticides for Pest Control Efficacy and Toxicity Reduction

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Solution Overview

Problem

Current methods for controlling invertebrate pests in agronomic and nonagronomic environments are limited by the need for more effective, less toxic, and environmentally safer compounds with different sites of action, as existing products often have limitations in efficacy and safety.

Innovation Solution

Development of substituted mesoionic compounds, their N-oxides, and salts, which are used in compositions as insecticides, including formulations for spray, bait, and seed treatment, to effectively control invertebrate pests by contacting the pests or their environments with biologically effective amounts of these compounds.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If existing insecticide products are used, then pest control function is provided, but efficacy is limited and toxicity is high

Engineering Contradiction:
Improvepest control efficacyVSAvoidtoxicity
Core Design Contradiction:
ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent applies parameter changes by modifying the chemical structure of insecticide compounds to create new mesoionic compounds with improved efficacy and reduced toxicity. The core invention involves changing molecular parameters (chemical composition, functional groups, substitution patterns) to achieve better pest control while lowering harmful effects on non-target organisms and the environment.

Inventive Principle:
Principle #35Parameter changes

2Reliability

If existing insecticide products are used, then pest control function is provided, but environmental safety is compromised

Engineering Contradiction:
Improvepest control effectivenessVSAvoidenvironmental safety
Core Design Contradiction:
ReliabilityVSObject-generated harmful factors

Solution Approach 1:

The patent modifies chemical parameters of insecticide molecules to develop mesoionic compounds that maintain pest control effectiveness while improving environmental safety. The structural modifications enable selective toxicity toward pests while reducing persistence and harm to beneficial organisms and ecosystems.

Inventive Principle:
Principle #35Parameter changes

3Reliability

If new mesoionic compounds are developed, then efficacy and environmental safety are improved, but compound complexity increases

Engineering Contradiction:
Improvepest control efficacyVSAvoidcompound structural complexity
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

The patent applies local quality by introducing specific functional groups and substitution patterns at particular positions within the mesoionic compound structure. This allows optimization of biological activity and environmental properties at specific molecular locations while maintaining the core compound framework, thereby managing complexity through targeted local modifications rather than complete structural redesign.

Inventive Principle:
Principle #3Local quality

Data Source

PatentEP4093738B1Mesoionic insecticides
Publication Date: 2024.03.06 FMC CORP
  • EP4093738B1 patent drawing
  • EP4093738B1 patent drawing
  • EP4093738B1 patent drawing

AI summary

Disclosed are compounds of Formula 1, including all geometric and stereoisomers, Ν-oxides, and salts thereof (I), wherein R1, X, Q, R2, n, R3 and R4 are as defined in the disclosure, Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound or a composition of the disclosure.