Mesosulfuron-methyl Crystalline Modification I Stability
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Solution Overview
Problem
The commercially available amorphous form of mesosulfuron-methyl is highly unstable and prone to hydrolysis when dissolved or stored, particularly in moist conditions, which affects its stability in formulations.
Innovation Solution
A novel crystalline form of mesosulfuron-methyl, termed 'crystalline modification I', is developed, which is more stable and can be prepared through dissolving the amorphous form in solvents like 1,1-dichloroethane or ethanol, followed by crystallization, and characterized by specific X-ray powder diffractogram reflexes and infrared spectroscopy, enhancing its stability and ease of formulation into agrochemical compositions.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If the amorphous form of mesosulfuron-methyl is used in formulations, then the compound can be manufactured and stored, but it undergoes significant hydrolysis and is highly unstable
Solution Approach 1:
The patent applies parameter changes by transforming the physical state of mesosulfuron-methyl from amorphous to crystalline form. This phase transition fundamentally alters the molecular packing and intermolecular forces, resulting in enhanced chemical stability and resistance to hydrolysis while maintaining the herbicidal activity of the compound.
Solution Approach 2:
The invention utilizes phase transitions to convert the amorphous form of mesosulfuron-methyl into a crystalline form through controlled crystallization processes. This phase change from disordered amorphous structure to ordered crystalline structure provides thermodynamic stability and prevents degradation via hydrolysis, directly addressing the reliability issue.
2Ease of operation
If the amorphous form of mesosulfuron-methyl is used, then the compound is easier to handle in certain formulations, but it is highly unstable and prone to hydrolysis
Solution Approach 1:
The patent changes the physical parameter of the compound from amorphous to crystalline state, which fundamentally alters its stability properties. The crystalline form maintains ease of formulation while providing superior stability against hydrolysis, resolving the contradiction between operational ease and reliability.
Solution Approach 2:
The invention creates a composite system by combining crystalline mesosulfuron-methyl with appropriate formulation carriers and excipients. This composite approach ensures both the stability of the crystalline form and the ease of formulation required for practical application, achieving both reliability and operational ease simultaneously.
3Reliability
If the crystalline form of mesosulfuron-methyl is prepared through dissolution and crystallization, then stability is improved, but the process requires additional steps
Solution Approach 1:
The patent employs phase transition through controlled crystallization to transform the amorphous form into the crystalline form. This phase change process, while adding a step, provides fundamental stability improvement that justifies the additional process complexity, and the crystallization can be optimized to minimize process steps.
Solution Approach 2:
The invention utilizes parameter changes in temperature, solvent composition, and cooling rates to control the crystallization process. By optimizing these parameters, the crystallization can be achieved efficiently with minimal additional steps, balancing the stability benefit against the process complexity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The crystalline modification I of mesosulfuron-methyl significantly reduces hydrolysis issues, making it suitable for various formulations such as suspension concentrates and granules, and is more effective in controlling undesirable plant growth with increased stability and ease of comminution.
Implementation Method 1
dissolving the amorphous form in solvents like 1,1-dichloroethane or ethanol, followed by crystallization
Implementation Method 2
followed by crystallization, and characterized by specific X-ray powder diffractogram reflexes
Data Source
AI summary
A crystalline form of mesosulfuron-methyl of formula (I), the crystal preparation process, the analyses of the crystal through various analytical methods and using the crystal to prepare stable agrochemical formulation. The invention also describes the use of various solvents towards the crystalline form preparation conditions.