Meta-diamide compounds for invertebrate pest control
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Solution Overview
Problem
Current methods for controlling invertebrate pests in agronomic and nonagronomic environments are limited by the need for more effective, less toxic, and environmentally safer compounds with different sites of action, as existing products often result in significant crop damage and increased costs.
Innovation Solution
Development of diamide compounds, their N-oxides, and salts, specifically formulated as compositions that include surfactants, solid or liquid diluents, and optionally additional biologically active agents, for effective pest control by contacting the pests or their environments.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If existing pest control products are used, then pest control is achieved, but crop damage increases and costs increase
Solution Approach 1:
The patent modifies the chemical structure of existing diamide compounds by substituting the R1 position with various groups (hydrogen, deuterium, fluorine, chlorine, bromine, or specific alkyl/alkenyl/alkynyl groups) to create new compounds with improved pest control effectiveness and reduced crop damage. This structural parameter change allows optimization of both efficacy and safety profiles.
Solution Approach 2:
The invention creates composite pest control solutions by combining the core diamide structure with various substituent groups at the R1 position, effectively creating a series of related compounds with different properties. This allows selection of the optimal compound for specific pest targets while minimizing harmful effects on crops.
2Reliability
If existing pest control products are used, then pest control is achieved, but toxicity increases and environmental safety decreases
Solution Approach 1:
By changing the R1 substituent parameters in the diamide compound structure, the patent optimizes the toxicological and environmental properties of the compounds. Specific substitutions (such as deuterium, fluorine, or specific alkyl groups) are chosen to reduce toxicity while maintaining or enhancing pest control effectiveness.
Solution Approach 2:
The patent converts the potential harm of existing diamide compounds by modifying their chemical structure to reduce unwanted effects. The structural modifications transform compounds with high toxicity into safer alternatives that maintain pest control efficacy, effectively turning a harmful substance into a beneficial one.
3Object-affected harmful factors
If new compounds with different sites of action are developed, then environmental safety is improved, but manufacturing complexity increases
Solution Approach 1:
The patent segments the diamide compound structure into a core structure and variable R1 substituent positions. This modular approach allows systematic exploration of different substituents to improve environmental safety while using established synthetic methods for the core structure, thereby managing manufacturing complexity.
Solution Approach 2:
The core diamide structure serves as a universal platform that can accommodate multiple different R1 substituents. This multi-functionality allows a single synthetic route to produce multiple environmentally safer variants, reducing overall manufacturing complexity compared to developing entirely new compounds.
Data Source
AI summary
Disclosed are compounds of Formula (1), N-oxides, and salts thereof, wherein Q, X, Y, A1, A2, L, R1, R2, R3, R4, R5, R6a, R6b, R7 and R8 are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula (1) and methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound or a composition of the disclosure.