Meta-genotype Determination System for Genetic Assay Integration
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Solution Overview
Problem
Current genetic assays often fail to provide comprehensive information needed for technological objectives such as blood typing, genetic profiling for drug responsiveness, and characterization of stem cell pluripotency, necessitating the combination of data from multiple assays.
Innovation Solution
A computer-implemented method and system that receive nucleic acid amplification data from biological samples, store and compare translation data to generate meta-genotypes, and display the results, enabling the determination of genetic patterns and meta-genotypes for various applications like blood typing.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If multiple genetic assays are used to determine comprehensive genetic results, then the completeness and accuracy of genetic information is improved, but the complexity of data integration and result determination worsens
Solution Approach 1:
The patent combines multiple genetic assay results into a unified meta-genotype determination system. The system integrates data from multiple assays (e.g., ABO blood group assay, Rh blood group assay) and merges them to determine comprehensive blood type information, resolving the complexity of handling multiple separate assays through a unified computational framework.
Solution Approach 2:
The patent introduces a computational system as an intermediary between raw genetic assay data and final genetic results. This intermediary system processes, integrates, and interprets data from multiple assays using algorithms and databases, simplifying the complex task of data integration and result determination while maintaining high accuracy.
2Reliability
If multiple genetic assays are performed to achieve comprehensive genetic profiling, then the reliability of genetic results is improved, but the time and resources required worsen
Solution Approach 1:
The patent implements preliminary action by pre-processing and organizing genetic assay data into standardized formats before integration. The system prepares data structures, validates inputs, and organizes assay results in advance, which streamlines the subsequent integration process and reduces overall processing time while maintaining reliability.
Solution Approach 2:
The patent ensures continuity of useful action by implementing an automated computational pipeline that continuously processes genetic assay data from multiple sources. The system maintains continuous operation in integrating and analyzing data streams, eliminating idle time and ensuring efficient utilization of resources throughout the genetic profiling process.
Data Source
AI summary
In one exemplary embodiment, a computer-implemented method for determining a genetic result from a biological sample is provided. The method includes receiving nucleic acid amplification data of a biological sample, by a processor, from a biological instrument. The method further includes storing translation data, in a memory. The translation data includes a pattern of assay values associated with possible genetic results. The method further includes comparing the translation data with the nucleic acid amplification data, by the processor, to generate the genetic result of the biological sample. Moreover, the method includes displaying the genetic result, on a display, to a user.