Metabolite Analysis for Chronic Valvular Disease Diagnosis
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Solution Overview
Problem
Early detection and treatment of chronic valvular disease in animals are challenging due to the lack of symptoms and the need for effective biomarkers to diagnose the condition.
Innovation Solution
Methods involving the analysis of biological samples for specific metabolites associated with chronic valvular disease, comparing their amounts to those in control animals, to diagnose the disease by determining if the metabolites are increased or decreased in the animal's sample.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If traditional diagnostic methods are used for chronic valvular disease, then the diagnosis can be made, but the detection is difficult due to the lack of symptoms and the disease progresses to severe stages
Solution Approach 1:
The patent applies preliminary action by measuring metabolite levels (nitrite, nitrate, and other metabolic markers) before the disease progresses to symptomatic stages. The method enables early detection by establishing baseline metabolite levels in healthy animals and comparing them to detect subtle changes indicating early CVD progression, allowing intervention before clinical symptoms appear.
2Reliability
If surgical or medical treatment is applied, then the disease can be treated, but nutritional intervention is preferred and requires early detection to be effective
Solution Approach 1:
The patent enables preliminary detection of CVD through metabolite analysis, allowing nutritional interventions to be initiated before the disease progresses to stages requiring surgery or medication. By detecting early metabolic changes associated with CVD, the method provides a time window for effective nutritional management that can prevent or delay disease progression.
3Measurement precision
If biomarkers are used for early detection, then the diagnosis can be made at minimal symptoms, but specific metabolite markers for CVD were previously unidentified
Solution Approach 1:
The patent applies self-service by utilizing the animal's own metabolic byproducts (nitrite, nitrate, and other metabolites) as diagnostic markers. These metabolites are naturally produced during normal metabolism and accumulate or change in specific patterns during CVD progression. The method requires no external tracers, implants, or complex labeling - simply measuring endogenous metabolic markers provides diagnostic information.
Data Source
AI summary
The invention provides methods for diagnosing chronic valvular disease in an animal. The methods comprise obtaining a sample from the animal; analyzing the sample for the presence of one or more metabolites associated with chronic valvular disease; comparing the amount of each such metabolite identified in the sample to a corresponding amount of the same metabolite present in a sample from one or more comparable control animals that do not suffer from chronic valvular disease; and using said comparison to diagnose chronic valvular disease in the animal if the metabolites found in the animal's sample is greater than or less than the amount present in the control animal's sample.