Metal-Based Coordination Complexes for Immunogen Inactivation
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Solution Overview
Problem
Current methods for treating and preventing coronavirus infections, particularly SARS-CoV-2, face challenges in stimulating an effective immune response in immunocompromised individuals, where vaccination and therapeutic interventions have limitations due to impaired immune function.
Innovation Solution
A method involving a metal-based coordination complex, represented by specific formulas, is added to an immunogenic composition to inactivate or attenuate the immunogen, which is then administered to elicit an immune response, potentially using electromagnetic radiation or ultrasound to activate the complex and enhance its effectiveness.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If vaccination and therapeutic interventions are used to treat coronavirus infections, then infection rates and severity are reduced, but these interventions are ineffective in immunocompromised patients due to impaired immune function
Solution Approach 1:
The patent introduces metal-based coordination complexes as intermediary agents that directly interact with the immunogen to inactivate or attenuate it before administration. These complexes serve as a bridge between the immunogen and the compromised immune system, modifying the immunogen's properties to make it suitable for patients with impaired immune function while still eliciting a protective immune response.
2Adaptability or versatility
If the immunogen is inactivated or attenuated using metal-based coordination complexes, then the immune response is effectively elicited in immunocompromised patients, but the complexity of the treatment method increases
Solution Approach 1:
The patent modifies the immunogen's parameters (inactivation or attenuation level) by controlling the interaction with metal-based coordination complexes. By adjusting parameters such as complex concentration, irradiation conditions, or contact time, the immunogen can be optimized for different patient populations, including immunocompromised individuals, without fundamentally changing the overall treatment approach.
3Reliability
If electromagnetic radiation or ultrasound is used to activate the metal-based coordination complex, then the inactivation or attenuation of the immunogen is enhanced, but the energy consumption and treatment complexity increase
Solution Approach 1:
The patent employs periodic or pulsed activation methods (electromagnetic radiation or ultrasound) to activate the metal-based coordination complexes. This periodic action allows for controlled energy delivery, activating the complexes only when needed to inactivate or attenuate the immunogen, thereby reducing overall energy consumption compared to continuous activation while maintaining treatment effectiveness.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach effectively elicits a therapeutic and protective immune response against coronavirus infections, including SARS-CoV-2, by inactivating or attenuating the virus, thereby improving prophylaxis and treatment outcomes in immunocompromised patients.
Implementation Method 1
Photo Dynamic Therapy (PDT) is a form of phototherapy which combines a photosynthesizing chemical substance and light to product singlet oxygen and/or Reactive Oxygen Species (ROS) to elicit cell death
Implementation Method 2
U.S. Pat. Nos. 6,962,910, 7,612,057, 8,445,475 and 8,148,360 disclose supramolecular metal complexes capable of cleaving DNA when irradiated with visible light
Data Source
AI summary
A method for eliciting an immune response in a patient includes the sequential steps of: providing an immunogenic composition including an immunogen; adding a metal-based coordination complex to the immunogenic composition to inactivate or attenuate the immunogen; and administering the immunogenic composition to the patient so as to elicit the immune response against the immunogen. A method for preparing an attenuated immunogenic composition includes the steps of: providing an immunogenic composition including an immunogen; and adding a metal-based coordination complex to the immunogenic composition to inactivate or attenuate the immunogen in the immunogenic composition to provide the attenuated immunogenic composition.