Metal Hydroxide Complex for Stable Active Ingredient Delivery

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Solution Overview

Problem

Existing methods for incorporating active ingredients in cosmetics, such as vitamins and α-hydroxy acids, face challenges related to stability, skin irritation, toxicity, sustained release, and dispersibility, which limit their practical applicability and effectiveness.

Innovation Solution

A metal hydroxide complex with a modified multilayer hydroxide structure, comprising a base layer, a surface layer, and an active ingredient, is developed. This complex is manufactured through a coprecipitation process using a precipitation reaction with alcohol and water, allowing for the stable inclusion of active ingredients in excess.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If active ingredients are incorporated into cosmetic formulations, then skin beauty and treatment effects are achieved, but stability problems and skin irritation occur

Engineering Contradiction:

Improvestability of active ingredientVSAvoidskin irritation and toxicity

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent incorporates active ingredients inside the interlayer spaces of metal hydroxide layered structures, creating a nested configuration where the active ingredient is protected within the host structure. This nesting approach stabilizes the active ingredient while controlling its release, thereby reducing skin irritation and toxicity without compromising efficacy.

Inventive Principle:

Principle #7Nested doll (Nesting)

Solution Approach 2:

The patent creates composite materials by combining metal hydroxide layers with active ingredients having carboxyl, hydroxyl, or phosphate groups. This composite structure leverages the stability of metal hydroxide and the functional properties of the active ingredient, achieving both stability and reduced harmful effects while maintaining cosmetic efficacy.

Inventive Principle:

Principle #40Composite materials

2Reliability

If conventional encapsulation methods are used to stabilize active ingredients, then stability is improved, but manufacturing complexity and time increase

Engineering Contradiction:

Improvestability of active ingredientVSAvoidmanufacturing process complexity

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The patent merges the stabilization function with the formulation process itself by directly incorporating active ingredients into metal hydroxide layered structures during synthesis. This eliminates separate encapsulation steps, reducing manufacturing complexity and time while achieving stable inclusion of active ingredients.

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

The patent utilizes parameter changes in pH and precipitation conditions to control the formation of metal hydroxide layered structures with incorporated active ingredients. By adjusting these parameters, the process achieves stable inclusion without requiring complex multi-step procedures, thereby simplifying manufacturing.

Inventive Principle:

Principle #35Parameter changes

3Reliability

If coating processes are added to treat active materials, then stability is improved, but the effect of the active ingredient is reduced and excess material is not included

Engineering Contradiction:

Improvestability of active ingredientVSAvoidamount of active ingredient

Core Design Contradiction:

ReliabilityVSQuantity of substance

Solution Approach 1:

The patent nests active ingredients within the interlayer spaces of metal hydroxide structures, allowing excess active ingredient to be incorporated without requiring additional coating steps. This nesting approach maintains the efficacy of the active ingredient while enabling higher inclusion amounts compared to conventional coating methods.

Inventive Principle:

Principle #7Nested doll (Nesting)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The metal hydroxide complex achieves excellent sustained release performance and stable storage of active ingredients, minimizing skin irritation and enhancing the delivery of active ingredients, thereby improving their efficacy and allowing for long-term storage.

Implementation Method 1

manufactured through a coprecipitation process using a precipitation reaction with alcohol and water

Methodology Applied

Scientific EffectCoprecipitation: Coprecipitation

Implementation Method 2

achieves excellent sustained release performance

Methodology Applied

Scientific EffectDiffusion: Diffusion

Implementation Method 3

stably included in excess inside the metal hydroxide complex

Methodology Applied

Scientific EffectDegradation: Decomposition (biological)

Data Source

PatentUS12297213B2Metal hydroxide complex comprising modified multilayer hydroxide structure comprising active ingredient and method of manufacturing same

Publication Date: 2025.05.13 CNPHARM CO LTD

AI summary

The present invention relates to a metal hydroxide complex including the multilayer hydroxide structure of Chemical Formula 1, including a base layer, a surface layer and an active ingredient, a metal hydroxide complex manufactured by subjecting an active ingredient and a metal hydroxide structure precursor to coprecipitation through a precipitation reaction using an alcohol and water, and a method of manufacturing the same.