Metal-Nucleic Acid Nanoparticles via Coordination Assembly
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Solution Overview
Problem
Current methods for producing DNA-based nanostructures are often complex and costly, necessitating a simpler and more effective approach for mass production of controllable DNA-based nanomaterials with unique functions.
Innovation Solution
A metal-nucleic acid nanoparticle is created using a coordination-directed self-assembly technique, combining metal ions with nucleic acids to form spherical structures that can be precisely controlled in size and shape, allowing for the incorporation of drug or fluorescent molecules for synergistic therapeutic effects and real-time monitoring.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If self-assemblable DNA nano-structures or template methods are used to synthesize DNA nano-structures, then the structures achieve controlled size and shape, but the production process becomes complex and costly
Solution Approach 1:
Metal ions serve as intermediary components that mediate between nucleic acid templates and the final nanoparticle structure. The metal ions coordinate with functional groups on the nanoparticle surface and with nucleic acid molecules, enabling controlled assembly into spherical structures with defined size and shape while simplifying the overall production process
Solution Approach 2:
The invention creates composite metal-nucleic acid nanoparticles by combining inorganic metal ion cores with organic nucleic acid shells. This composite structure integrates the size-control advantages of DNA self-assembly with the simplicity of metal nanoparticle synthesis, achieving both manufacturing precision and process simplicity
2Adaptability or versatility
If traditional DNA-based nanostructure methods are used, then functional control is achieved, but mass production becomes difficult
Solution Approach 1:
The nanoparticle synthesis is segmented into independent stages: first forming metal nanoparticle cores with controlled size, then assembling nucleic acid shells around them. This segmentation allows each stage to be optimized independently, enabling both functional control and scalability for mass production
Solution Approach 2:
The nucleic acid molecules self-assemble around the metal nanoparticle cores through coordination interactions, without requiring complex external guidance or purification steps. This self-service mechanism simplifies the production process while maintaining functional control, facilitating mass production
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method enables the production of metal-nucleic acid nanoparticles that can target tumor tissues, release therapeutic agents, and provide real-time monitoring capabilities, while being suitable for mass production and simple to implement.
Implementation Method 1
a nanoparticle having a spherical structure formed by combining a metal ion with a nucleic acid via coordination
Data Source
AI summary
The present application relates to a metal-nucleic acid nanoparticle which is a nanoparticle having a spherical structure formed by assembly of metal ions with nucleic acids via coordination. The preparation thereof is mixing a metal ion solution with a nucleic acid solution to obtain a mixture followed by vortex, heating, centrifugation, washing with water and resuspension to obtain the metal-nucleic acid nanoparticles.