Metal-Organic Framework Coatings for Nitric Oxide Release
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current medical devices face complications due to incompatibility with human blood and tissue, leading to issues like thrombosis, inflammation, cell proliferation, and infection, and existing nitric oxide-releasing materials have inadequate NO loading dosages and structural limitations, making them unsuitable for long-term clinical use.
Innovation Solution
Development of a modular biomaterial using metal-organic frameworks that release nitric oxide, capable of producing therapeutic amounts for extended periods while maintaining structural integrity, by combining metals with organic linkers and incorporating nitric oxide-releasing functional groups, such as S-nitrosothiols or diazeniumdiolates, to create stable and biocompatible coatings for medical devices.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional materials are used for medical devices, then device simplicity and ease of manufacture are maintained, but device failures occur due to thrombosis, inflammation, cell proliferation, and infection
Solution Approach 1:
The patent uses composite materials consisting of metal-organic frameworks (MOFs) integrated with medical device surfaces. These composites combine the structural integrity of metals with the functional properties of organic linkers that can release nitric oxide, thereby reducing device failures from thrombosis and infection while maintaining manufacturability through coating applications
2Reliability
If systemic drug therapies are administered to prevent device complications, then thrombosis and inflammation are reduced, but systemic side effects and increased morbidity occur
Solution Approach 1:
The patent employs nitric oxide-releasing metal-organic frameworks as intermediary materials that locally deliver therapeutic nitric oxide at the device-tissue interface. This localized delivery mechanism prevents systemic circulation of drugs, thereby eliminating systemic side effects while maintaining anti-thrombotic and anti-inflammatory effects at the implant site
Solution Approach 2:
The invention implements local quality by concentrating nitric oxide release functionality directly at the blood-contacting surface of the device through MOF coatings. This localized therapeutic action provides high drug concentration where needed while avoiding systemic exposure, thus preventing complications without causing systemic morbidity
3Reliability
If existing nitric oxide-releasing materials are used, then some thromboresistivity is achieved, but inadequate NO loading dosages and short duration of action limit clinical utility
Solution Approach 1:
The patent utilizes parameter changes by systematically varying the metal nodes and organic linker compositions in metal-organic frameworks to optimize nitric oxide loading capacity and release kinetics. This modular approach enables tuning of NO release duration from hours to weeks, providing sustained thromboresistivity and extending clinical utility beyond short-term applications
Solution Approach 2:
The invention employs porous metal-organic framework structures that provide high surface area and internal volume for nitric oxide storage. The porous architecture enables increased NO loading dosages while controlling release rates through pore size and surface chemistry, thereby achieving both high capacity and sustained duration of action
4Reliability
If material modifications are made to reduce device complications, then biocompatibility improves, but mechanical properties and structural integrity are altered
Solution Approach 1:
The patent applies segmentation by separating the structural function (provided by the base device material) from the therapeutic function (provided by the MOF coating). This functional segmentation allows the underlying device to maintain its mechanical integrity while the surface coating provides biocompatibility enhancements through nitric oxide release without compromising structural strength
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The modular biomaterials provide sustained nitric oxide release, reducing thrombosis, inflammation, and cell proliferation, while maintaining mechanical properties, thus enhancing the longevity and safety of medical devices and reducing healthcare costs.
Implementation Method 1
incorporating nitric oxide-releasing functional groups, such as S-nitrosothiols or diazeniumdiolates, to create stable and biocompatible coatings
Implementation Method 2
Metal-organic compounds have open spaces and pores that allow for the absorption and/or chemical reaction with small molecules, such as nitric oxide
Data Source
Figure 1~2
Figure 3a~3b
Figure 4~5
AI summary
The present disclosure is directed to a method of producing nitric oxide comprising (i) providing a composition comprising a metal-organic framework, and (ii) exposing the composition to a nitric oxide-releasing compound. The disclosure also is directed to compositions, coatings, and medical devices comprising a metal-organic framework.