Metal-Based Particle Assembly for Enhanced Luminescent Sensing
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Solution Overview
Problem
Conventional optical biosensing apparatuses face challenges in achieving high-sensitivity analysis due to low emission intensity from luminescent substances, especially when the analyte amount is small, often requiring multiple measurements or failing to detect the substance.
Innovation Solution
A metal-based particle assembly with specifically arranged metal particles, where the average interparticle distance and standard deviation are controlled within certain ranges, forming a plasmonic structure that enhances luminescent emission over a broader range, improving sensitivity in optical sensing apparatuses.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If conventional optical biosensing apparatuses use luminescent substances for detection, then the apparatus can perform qualitative or quantitative analysis, but the emission intensity from the luminescent substance is low, requiring high-sensitivity spectrometers and multiple measurements
Solution Approach 1:
The patent changes the physical parameters of the metal particles (size: 5-800 nm, interparticle distance: 1-1000 nm with standard deviation ≤25 nm) to optimize plasmon resonance effects. By controlling these parameters, the system achieves enhanced emission intensity without requiring high-sensitivity spectrometers, resolving the contradiction between detection sensitivity and emission intensity
Solution Approach 2:
The patent creates a composite structure combining metal particles (silver, gold, aluminum, or their alloys) with luminescent substances. This composite system exploits localized plasmon resonance of the metal particles to enhance the emission from the luminescent substance, achieving high detection sensitivity without requiring expensive high-sensitivity spectrometers
2Quantity of substance
If the amount of analyte is small, then the analysis should be more sensitive, but high-sensitivity analysis becomes more difficult and may require multiple measurements or fail to detect the substance
Solution Approach 1:
The patent optimizes the interparticle distance parameter (1-1000 nm with standard deviation ≤25 nm) to maximize plasmon resonance enhancement effects. This parameter control enables the system to detect small amounts of analyte with high sensitivity, eliminating the need for multiple measurements even when analyte quantity is low
3Illumination intensity
If conventional plasmonic structures are used to enhance luminescent emission, then the emission intensity is enhanced, but the range of plasmon resonance effect is limited to a narrow distance from the surface
Solution Approach 1:
The patent transitions from conventional two-dimensional metal film structures to three-dimensional metal particle assemblies with controlled spatial distribution. By arranging particles in three-dimensional space with specific size and distance parameters, the system extends the plasmon resonance enhancement effect to a broader spatial range while maintaining enhanced emission intensity
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The structured metal-based particle assembly enhances luminescent emission intensity and extends the range of plasmon resonance effect, enabling improved sensitivity and detection capabilities even at greater distances from the surface, effectively addressing the limitations of conventional plasmonic structures.
Implementation Method 1
Patent Literature 1 discloses a technique exploiting localized plasmon resonance phenomenon for enhanced fluorescence
Data Source
AI summary
Provided are a metal-based particle assembly including a plurality of metal-based particles arranged apart from each other, wherein the plurality of metal-based particles are each arranged so that an average distance between metal-based particles adjacent to each other is 1 nm or more and 1000 nm or less, and a standard deviation of the average distance is 25 nm or less; a layered body including the metal-based particle assembly; and a sensing apparatus including the layered body, a capturing layer that is arranged on the metal-based particle assembly and has a capturing substance for capturing an analyte, the analyte being labeled with a luminescent substance, a light-transmitting member, a light source that emits excitation light for exciting the luminescent substance, and a detector that detects emission from the luminescent substance.