Metal Salen Complex Ointment for Targeted Drug Delivery

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Solution Overview

Problem

Current drug delivery systems face challenges in efficiently targeting affected sites without causing adverse reactions in normal tissues, particularly for invasive treatments like tongue cancers and postorbital tissues, where existing methods are invasive and ineffective.

Innovation Solution

An ointment containing a metal-salen complex compound is developed, which can be efficiently transferred to affected sites using a magnetic field, minimizing invasiveness and maximizing drug concentration at the target area.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Quantity of substance

If conventional drug delivery methods are used to administer antitumor agents systemically, then the drug can reach affected sites, but adverse reactions occur in normal tissues with active cell division

Engineering Contradiction:

Improvedrug concentration at affected siteVSAvoidadverse reactions in normal tissue

Core Design Contradiction:

Quantity of substanceVSObject-affected harmful factors

Solution Approach 1:

The patent introduces a magnetic nanoparticle carrier as an intermediary to transport the antitumor drug. The magnetic carrier enables targeted delivery to the affected site through external magnetic field guidance, preventing direct systemic circulation that causes adverse reactions in normal tissues

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The invention creates localized high concentration of the drug at the affected site through magnetic targeting, while maintaining low or zero concentration in normal tissues. This spatial differentiation of drug concentration resolves the contradiction between achieving therapeutic efficacy and avoiding systemic toxicity

Inventive Principle:

Principle #3Local quality

2Reliability

If lidocaine is injected into spinal fluid for spinal anesthesia, then anesthesia effect is achieved, but there is risk of respiratory function cessation due to cervical spinal cord exposure

Engineering Contradiction:

Improveanesthesia effectVSAvoidrespiratory function cessation risk

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The magnetic nanoparticle carrier acts as an intermediary that can be precisely guided to the intended target site using external magnetic fields. This controlled delivery mechanism prevents uncontrolled spread of the anesthetic through spinal fluid, eliminating the risk of cervical spinal cord exposure while maintaining reliable anesthesia effect

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The system enables real-time monitoring and control of drug delivery through magnetic field guidance. The magnetic carrier responds to external magnetic field adjustments, allowing precise positioning at the target site and preventing unintended distribution to sensitive areas like the cervical spinal cord

Inventive Principle:

Principle #23Feedback

3Ease of manufacture

If invasive treatment methods are used for tongue cancers and postorbital tissues, then treatment can be administered, but patient burden and invasiveness increase

Engineering Contradiction:

Improvetreatment applicabilityVSAvoidinvasiveness and patient burden

Core Design Contradiction:

Ease of manufactureVSEase of operation

Solution Approach 1:

The magnetic nanoparticle carrier serves as a minimally invasive intermediary for delivering treatment to difficult-to-reach sites like tongue cancers and postorbital tissues. The carrier can be administered through simple routes (injection or topical application) and then guided magnetically to the target, avoiding complex surgical procedures while maintaining treatment effectiveness

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The invention replaces invasive mechanical surgical procedures with a magnetic field-based delivery system. Instead of requiring open surgery or complex mechanical intervention to reach difficult sites, the magnetic carrier system uses non-contact magnetic guidance to deliver treatment, significantly reducing invasiveness and patient burden

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The ointment effectively concentrates the drug at the target site, reducing adverse reactions in normal tissues and enhancing therapeutic efficacy, as demonstrated by its ability to inhibit melanoma growth and other cancer treatments.

Implementation Method 1

which can be efficiently transferred to affected sites using a magnetic field

Methodology Applied

Scientific EffectMagnetic field: Magnetic Field

Data Source

PatentEP2738158B1Metal salen complex compound, local anesthetic, and Anti-malignant tumor agent

Publication Date: 2019.04.24 IHI CORP

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AI summary

A metal-salen complex compound, which exhibits excellent noninvasiveness and can be efficiently transferred to an affected site, a local anesthetic containing this metal-salen complex compound, and an antineoplastic drug containing this metal-salen complex compound are provided. Regarding the metal-salen complex compound, a metal atom part in each of two molecules of a metal-salen complex or a derivative of the metal-salen complex is dimerized via water, and the metal-salen complex compound is mixed with a base to produce an ointment.