Veterinary Methisoprinol Preparation Using Polyhydric Alcohols
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Methisoprinol, a compound with immunomodulating and antiviral properties, is challenging to administer orally due to its bitter taste, making it difficult for both humans and animals, and its short activity duration necessitates high daily doses, limiting its veterinary application.
Innovation Solution
A veterinary preparation containing 15-30% methisoprinol, dissolved or suspended in polyhydric alcohols with preservatives and gelling agents like phenol and cellulose derivatives, allowing for easy oral administration and prolonged activity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If methisoprinol is administered orally in water solution form, then it can be given easily to animals, but the bitter taste makes voluntary oral administration difficult
Solution Approach 1:
The patent uses polyhydric alcohols (such as glycerol, sorbitol, xylitol, mannitol) as intermediary substances to dissolve methisoprinol. These alcohols serve as mediators between the active substance and the animal's taste receptors, masking the bitter taste while maintaining the drug's bioavailability and enabling easy voluntary oral administration.
Solution Approach 2:
The patent changes the physical-chemical parameters of the solvent from water to polyhydric alcohols. This parameter change fundamentally alters the taste profile of the solution, transforming it from bitter to palatable, while preserving the therapeutic efficacy of methisoprinol.
2Duration of action of moving object
If high daily doses of methisoprinol are administered to achieve prolonged activity, then the activity duration is extended, but the administration becomes more complex and stressful for animals
Solution Approach 1:
The patent changes the concentration parameter of methisoprinol in the polyhydric alcohol solution to optimize both duration of action and ease of administration. By adjusting the dosage form and concentration, the patent achieves prolonged therapeutic effect without requiring stressful high-dose administrations, making the treatment easier to administer while maintaining extended activity duration.
Data Source
AI summary
The preparation contains preferably up to 30% (especially 15-25%) by weight of methisoprinol. Methisoprinol is preferably dissolved in water. Another form is a solution of methisoprinol in polyhydric alcohol, where the alcohol is propylene glycol or sorbitol. The preparation also contains excipients and additional ingredients. Methisoprinol has also been proved effective against papillomas.