MgO Osteostimulative Implant Surface for Bone Integration
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Solution Overview
Problem
Existing bone implants face issues with loosening due to inadequate integration, leading to compromised stability, decreased patient comfort, and increased expenses, with materials like PMMA causing thermal necrosis and calcium phosphate cement lacking adhesive properties and having a long absorption time, necessitating immediate application that complicates the procedure.
Innovation Solution
A bone-implantable device with an exterior surface containing a cured osteostimulative material comprising MgO, KH2PO4, and magnesium phosphate, which is bioresorbable and provides osteoconductive and osteoinductive properties, enhancing bone integration and fusion.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of manufacture
If PMMA is used as bone cement, then the implant can be readily applied and provides immediate structural support, but it causes thermal necrosis and wear particle formation leading to implant failure
Solution Approach 1:
The patent changes the chemical composition parameters of the bone cement by incorporating calcium phosphate and magnesium phosphate compounds, replacing traditional PMMA. This parameter change maintains the cement's applicability while eliminating thermal necrosis and wear particle formation issues through biodegradable, bioactive materials that integrate with bone tissue.
Solution Approach 2:
The patent uses composite materials combining calcium phosphate and magnesium phosphate compounds with appropriate binders and adjuvants. This composite formulation provides both the structural support needed for immediate application and the biocompatibility required to avoid thermal necrosis, while promoting bone integration through osteoconductive properties.
2Strength
If calcium phosphate cement is used, then it provides osteoconductive properties and high compressive strength, but it lacks adhesive properties and has a long absorption time
Solution Approach 1:
The patent creates a composite bone cement formulation combining calcium phosphate and magnesium phosphate compounds with adhesive binders and surface treatment agents. This composite structure maintains the high compressive strength and osteoconductive properties of calcium phosphate while adding adhesive capabilities through the binder system and surface modification to ensure strong bonding to implant surfaces and surrounding bone.
Solution Approach 2:
The patent modifies the physical and chemical parameters of the calcium phosphate-based cement by incorporating magnesium phosphate and adhesive agents. These parameter changes enhance the adhesive properties and control the absorption rate, allowing the material to maintain strength while improving bonding characteristics and reducing the time to achieve adequate integration.
3Loss of time
If osteostimulative material is applied immediately before implantation, then the procedure time is reduced, but the risk of uneven application increases
Solution Approach 1:
The patent incorporates osteostimulative material directly into the implant structure during manufacturing, performing the application action in advance under controlled conditions. This preliminary action ensures uniform distribution and proper adhesion of the osteostimulative material to the implant surface before implantation, eliminating the risks associated with intraoperative application while maintaining reduced procedure time.
Solution Approach 2:
The patent uses additive manufacturing or precision coating techniques to create a precise copy or replica of the optimal material distribution pattern directly on the implant. This copying process ensures uniform application of the osteostimulative material according to the designed geometry, achieving both time efficiency and application precision by eliminating manual application variability.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device achieves improved bone-implant integration, stability, and reduced procedure time by providing a bioresorbable material that adheres to bone, promotes healing, and is easily applied, reducing the risk of uneven application and thermal damage.
Implementation Method 1
the material should adhere implant to bone, tolerate and transfer loads on the implant to bone, promote bone healing
Implementation Method 2
An assortment of osteoinductive and osteoconductive materials has been used to fill bone defects and to anchor implants to bone
Implementation Method 3
be readily absorbed at a rate that allows adequate time for osseointegration
Data Source
AI summary
The present disclosure provides a bone-implantable device and methods of use. The bone-implantable device comprises a body having an exterior surface, wherein a portion of the exterior surface includes a cured osteostimulative material comprising MgO.