Parallel MHC Purification via Stepped Gradient Chromatography

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Solution Overview

Problem

Existing methods for producing MHC molecules are time-consuming and labor-intensive, resulting in significant protein losses due to the need for concentration and buffer exchange steps, making it inefficient for producing multiple differing MHC-peptide molecules.

Innovation Solution

A method involving parallel chromatographic purification using a stepped gradient for elution, which eliminates the need for concentration steps and allows for the simultaneous processing of multiple subsets of MHC molecules, maintaining high yields and reducing protein losses.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Productivity

If traditional sequential purification methods are used for MHC molecules, then purification can be achieved, but the process is time-consuming and labor-intensive with significant protein losses

Engineering Contradiction:
Improvepurification efficiencyVSAvoidproduction time
Core Design Contradiction:
ProductivityVSLoss of time

Solution Approach 1:

The patent divides the purification process into separate parallel chromatography streams, where each stream processes a different MHC molecule subset independently. This segmentation allows simultaneous purification of multiple MHC variants without sequential processing, directly resolving the contradiction between productivity and time loss.

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The patent combines multiple purification operations into a single integrated system where parallel chromatography columns operate simultaneously. By merging the purification functions into one coordinated process rather than separate sequential steps, the system achieves high productivity while maintaining low production time.

Inventive Principle:
Principle #5Merging (Combining)

2Reliability

If concentration and buffer exchange steps are performed, then MHC molecules can be purified, but considerable protein losses occur

Engineering Contradiction:
Improvepurification qualityVSAvoidprotein loss
Core Design Contradiction:
ReliabilityVSLoss of substance

Solution Approach 1:

The patent extracts and eliminates the problematic concentration and buffer exchange steps from the purification process. By using chromatographic methods that directly purify MHC molecules in their native buffers without requiring concentration or exchange steps, the system maintains purification quality while preventing protein losses.

Inventive Principle:
Principle #2Taking out (Extraction)

Solution Approach 2:

The patent introduces chromatographic separation as an intermediary mechanism that enables direct purification without needing concentration or buffer exchange steps. The chromatography system acts as a mediator that achieves both purification quality and protein conservation simultaneously.

Inventive Principle:
Principle #24Intermediary (Mediator)

3Adaptability or versatility

If multiple different MHC-peptide molecules are produced using traditional methods, then diversity is achieved, but the process becomes increasingly time-consuming and labor-intensive

Engineering Contradiction:
ImproveMHC molecule diversityVSAvoidproduction complexity
Core Design Contradiction:
Adaptability or versatilityVSEase of manufacture

Solution Approach 1:

The patent creates a universal parallel purification system that can simultaneously process multiple different MHC molecule subsets with varying peptides, alpha chains, and beta chains. This multi-functional system maintains ease of manufacture by using the same chromatographic methodology across all subsets while achieving high diversity.

Inventive Principle:
Principle #6Universality (Multi-functionality)

Solution Approach 2:

The patent segments the production process into parallel independent streams, where each stream handles a specific MHC subset. This segmentation allows the system to maintain simplicity in each individual stream while achieving complexity in the overall output diversity, resolving the contradiction between adaptability and ease of manufacture.

Inventive Principle:
Principle #1Segmentation

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This approach enables the efficient production of high-yield, diverse MHC molecules at reduced costs, suitable for screening applications, by applying similar purification methods to subsets with differing peptides, alpha, and beta chain proteins, thereby overcoming the limitations of traditional methods.

Implementation Method 1

purifying substantially in parallel the subsets of MHC molecules as obtained in step a) by a chromatographic method using a stepped gradient for elution

Methodology Applied
Scientific EffectChromatography: Chromatography

Data Source

PatentEP1879918B1Method of producing a set of MHC molecules
Publication Date: 2013.05.08 PROIMMUNE

AI summary

The present invention relates to a method of producing a set of MHC molecules, and more precisely to a method of producing a set of MHC molecules which differ in their peptide bound in the binding groove. The method allows for parallel and rapid synthesis of different MHC molecules at high yields for each molecule.