Magneto-Hydrodynamic Device for Localized Drug Delivery
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current methods for localized drug delivery and extraction of substances from targets, such as articular cartilage, bone, and nails, face challenges due to high density and lack of vascularity, leading to systemic distribution rather than targeted delivery, and existing devices suffer from inefficiencies in fluid recirculation and potential for rapid degradation.
Innovation Solution
A device utilizing magneto-hydrodynamics (MHD) with a frame containing conductive fluid, aligned electrodes, and a magnetic field perpendicular to the electric current, allowing for controlled movement of the fluid towards or from the target, enabling localized delivery and extraction by inducing a Lorentz force that synchronizes electric current and magnetic field to direct fluid flow.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If needle-free injector devices use MHD to induce high-pressure fluid jet to penetrate skin, then injection without needles is achieved, but the fluid ejection lasts only a few microseconds limiting exposure time and drug diffuses systemically after crossing skin
Solution Approach 1:
The patent employs alternating current to continuously actuate the conductive fluid through the target tissue, maintaining fluid motion and Lorentz force application over an extended period rather than a single microsecond pulse, thereby achieving sustained drug delivery without needle penetration
2Productivity
If integrated electro-magneto hydrodynamic micro pumps actuate fluid in the whole transverse area of the channel, then fluid pumping is achieved, but adequate recirculation is prevented when aperture is obstructed and rapid degradation of conductive fluid occurs
Solution Approach 1:
The patent segments the electrode configuration into first and second electrodes positioned to define a specific volume, creating a controlled current path through the conductive fluid that enables focused actuation and facilitates recirculation patterns even when aperture obstruction occurs
Solution Approach 2:
The patent utilizes alternating current applied to the electrodes to periodically actuate the conductive fluid, creating oscillating flow patterns that enhance recirculation within the defined volume and prevent stagnation, thereby maintaining fluid stability and preventing rapid degradation
3Quantity of substance
If conventional methods deliver drugs systemically through circulatory system, then drug distribution throughout body is achieved, but localized delivery to specific tissues is not accomplished
Solution Approach 1:
The patent applies local quality by concentrating the electromagnetic actuation and drug delivery to a specific localized volume between the first and second electrodes, creating spatially selective drug deposition in target tissue rather than systemic distribution, thereby achieving precise localized therapy
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach allows for non-destructive, localized delivery and extraction of materials, reducing systemic side effects and maintaining effective drug dosages by recirculating the actuated fluid and minimizing power dissipation and heating, with applications in delivering drugs to dense and avascular tissues and extracting substances from targets.
Implementation Method 1
a magnet adapted to produce a magnetic field to the volume, the magnetic field being substantially perpendicular to the electric current
Implementation Method 2
Device and method for localized delivery and extraction of material exploiting magneto-hydrodynamics (MHD)
Data Source
AI summary
The present invention relates to a device exploiting magneto-hydrodynamics (MHD) for localized delivery of material into a target or extraction of material from a target. The device includes a frame (101) comprising a space (102) for conductive fluid and the material, at least one pair of electrodes (103A, 103B) facing each other, a source of electric current (105), a magnet (105), and an opening (106). The electric current and the magnetic field are synchronized so that the material can be moved from the volume between the electrodes through the opening towards the target or from the target through the opening towards the volume. According to the invention the volume is ≤2000 mm3, in proviso that mean distance between tips of the electrodes is ≤20 mm.