Micro-Cavity Patch for Tissue Diagnosis
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Solution Overview
Problem
Conventional tissue diagnosis methods require large amounts of washing solution and may interfere with accurate detection if the washing process is not properly performed, leading to the need for a method that effectively removes interfering factors while minimizing the amount of specimen required.
Innovation Solution
A patch with a mesh structural body forming micro-cavities is used to contain a substance, providing a reaction space and allowing for the detection of target substances in tissue samples by using fluorescence or color labeling substances.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If a conventional washing process is used to remove staining reagent or fluorescent substances, then the interfering factors are removed, but a large amount of washing solution is required
Solution Approach 1:
The patent extracts and removes the washing step entirely from the diagnostic process. Instead of using washing solution to remove interfering substances, the micro-cavity patch structure physically contains the labeling substance and presents it directly to the tissue sample, eliminating the need for washing and thereby removing interfering factors without requiring large amounts of washing solution
Solution Approach 2:
The micro-cavity patch acts as an intermediary device between the labeling substance and the tissue sample. It provides a controlled reaction space where labeling occurs, and its structure prevents the need for washing steps while ensuring accurate detection, thus mediating the interaction without requiring additional washing solution
2Reliability
If a conventional washing process is used to remove staining reagent or fluorescent substances, then the interfering factors are removed, but the washing process may interfere with accurate detection if not properly performed
Solution Approach 1:
The patent extracts the washing process from the diagnostic workflow and replaces it with a direct labeling and detection approach using micro-cavity patches. This eliminates the complexity of controlling washing parameters while maintaining or improving detection accuracy through the structured presentation of labeling substances
Solution Approach 2:
The micro-cavity patch structure is self-sufficient in providing the labeling function. The patch itself contains and presents the labeling substance in a controlled manner, eliminating the need for external washing steps and reducing process complexity while ensuring accurate detection
3Measurement precision
If a large amount of specimen is used for diagnosis, then accurate detection can be achieved, but the amount of specimen required increases
Solution Approach 1:
The patent applies local quality by concentrating the labeling substance within micro-cavities of the patch structure. This localized concentration enhances the labeling efficiency and detection sensitivity, allowing accurate detection with smaller amounts of tissue specimen. The micro-cavity structure provides a focused reaction space that maximizes the interaction between labeling substance and target antigens
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The patch enables prompt and accurate tissue diagnosis by minimizing the amount of specimen and washing solution required, while effectively removing interfering factors and allowing for the simultaneous detection of multiple targets.
Implementation Method 1
a mesh structural body forming micro-cavities and is configured to contain a substance in the micro-cavities
Implementation Method 2
providing the labeling substance to the reaction region... a labeling substance that specifically labels the target substance
Data Source
AI summary
The present disclosure relates to a tissue diagnosis device including a plate supporter configured to support a plate on which a reaction region is placed and a sample is placed in the reaction region, a patch controller configured to support the patch which contains a labeling substance that specifically labels the target substance, and control a position of the patch relative to the reaction region so that the patch provides the labeling substance to the reaction region, and a target substance detector configured to detect the labeling substance and detect the target substance included in the tissue sample.