Micro Filter Sepsis Diagnosis Using CD64 and PCT Thresholds
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Solution Overview
Problem
Current diagnostic methods for sepsis are inaccurate, time-consuming, and lack specificity, leading to high mortality rates due to delayed detection, particularly in elderly patients with compromised immune systems.
Innovation Solution
A method using an analysis device with a micro filter to capture neutrophil CD64 cells and procalcitonin (PCT) polymers bound to fluorescent materials, analyzing light transmission to determine sepsis through a light source, photosensitive part, display, and analysis part, setting thresholds for CD64 cell count and PCT concentration to differentiate bacterial and viral sepsis.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If commonly used biomarkers (CRP, PCT, TNF, IL-6) are used for diagnosis, then diagnostic coverage is achieved, but diagnostic precision and reliability deteriorate due to non-specific properties
Solution Approach 1:
The patent segments the diagnostic approach by dividing sepsis detection into two distinct biomarker measurements: neutrophil CD64 cell count and procalcitonin (PCT) concentration. This segmentation allows each biomarker to be measured and evaluated separately, with specific threshold values (CD64 ≥1000 cells/μl and PCT ≥0.5 ng/mL) that improve diagnostic specificity while maintaining comprehensive coverage
Solution Approach 2:
The patent changes the diagnostic parameters by establishing specific threshold values for CD64 cell count (1000 cells/μl) and PCT concentration (0.5 ng/mL). These parameter changes transform the diagnostic process from qualitative clinical assessment to quantitative measurement with defined cutoffs, thereby improving both reliability and precision
2Loss of time
If traditional diagnostic methods are used, then clinical experience can be applied, but diagnosis time increases and early detection capability deteriorates
Solution Approach 1:
The patent applies preliminary action by establishing predetermined threshold values for CD64 (1000 cells/μl) and PCT (0.5 ng/mL) before actual diagnosis. This allows rapid comparison of measured values against pre-set criteria, enabling quick decision-making without requiring complex clinical reasoning or extended analysis time
Solution Approach 2:
The patent replaces the mechanical system of clinical experience-based judgment with an automated measurement and comparison system. The diagnosis is determined by objectively comparing quantified biomarker levels against established thresholds, eliminating subjectivity and reducing diagnosis time while improving early detection accuracy
3Measurement precision
If clinical determination based on medical staff experience is used, then diagnostic flexibility is maintained, but diagnostic accuracy deteriorates due to subjectivity
Solution Approach 1:
The patent changes the diagnostic approach from subjective clinical judgment to objective parameter measurement by quantifying CD64 cell count and PCT concentration with specific threshold values. This transformation improves diagnostic accuracy by replacing subjective assessment with measurable, comparable data points
Solution Approach 2:
The patent creates a universal diagnostic criterion that can be applied across different clinical settings and by different medical professionals. The standardized thresholds for CD64 (1000 cells/μl) and PCT (0.5 ng/mL) provide a common reference framework that eliminates variability introduced by individual clinical experience differences
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables rapid and reliable early diagnosis of sepsis, reducing mortality by accurately distinguishing between bacterial and viral infections, improving patient outcomes.
Implementation Method 1
a micro filter having micro filtration holes... an operation of simultaneously capturing, by the micro filter, neutrophil CD64 cells and a PCT polymer from the blood sample
Implementation Method 2
a light source part which radiates light directly toward the micro filter, a photosensitive part which detects light passing through the micro filter
Implementation Method 3
forming, in a blood sample to be analyzed, neutrophil Cluster of Differentiation (CD)64 cells to which a fluorescent material is bound and a procalcitonin (PCT) polymer to which a fluorescent material is bound
Data Source
AI summary
Provided is a method for performing early diagnosis of sepsis using an analysis device including a micro filter. The method includes an operation of forming, in a blood sample to be analyzed, neutrophil Cluster of Differentiation (CD)64 cells to which a fluorescent material is bound and a procalcitonin (PCT) polymer to which a fluorescent material is bound and beads are applied; an operation of simultaneously capturing, by the micro filter, neutrophil CD64 cells and a PCT polymer from the blood sample; an operation of radiating, by the light source part, light toward the micro filter; an operation of detecting, by the photosensitive part, light passing through the micro filter; an operation of outputting, by the display part, information acquired using the photosensitive part; and an operation of analyzing, by the analysis part, an image displayed on the display part to determine whether there is sepsis.