Micro Flow Channel Actuator for Homogeneous Mixing

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Solution Overview

Problem

Conventional micro flow channel test devices suffer from low reaction efficiency due to laminar flow and incomplete mixing of tested chemicals with reactants, leading to ineffective antigen-antibody reactions, even when the fluid is reciprocated to re-enter the reaction zone.

Innovation Solution

A test device with a micro flow channel and an actuator that homogenizes the density distribution of tested chemicals by oscillating the fluid within the channel, ensuring even distribution and increased interaction with reactants fixed in the reaction part, enhancing reaction efficiency.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Productivity

If the tested fluid is reciprocated in the micro flow channel to improve reaction efficiency, then the tested chemical can be sent closer to the reaction part, but the flow remains laminar and the tested chemical does not blend in the tested fluid

Engineering Contradiction:
Improvereaction efficiencyVSAvoidlaminar flow stability
Core Design Contradiction:
ProductivityVSStability of the object's composition

Solution Approach 1:

The patent introduces a vibration element that vibrates the tested fluid in the micro flow channel, creating turbulent flow conditions that promote mixing of the tested chemical with the reactant. This mechanical vibration disrupts the stable laminar flow pattern, enabling effective blending and contact between reactants while maintaining the micro flow channel structure.

Inventive Principle:
Principle #18Mechanical vibration

Solution Approach 2:

The patent changes the flow regime parameter from laminar to turbulent by introducing vibration. This parameter change transforms the flow characteristics, allowing the tested fluid to mix effectively with the reactant while maintaining controlled flow conditions through the micro flow channel during reciprocation.

Inventive Principle:
Principle #35Parameter changes

2Productivity

If the micro flow channel depth is reduced to improve reaction efficiency, then the tested chemical can be closer to the reaction part, but the fluid sending pressure rises excessively

Engineering Contradiction:
Improvereaction efficiencyVSAvoidfluid sending pressure
Core Design Contradiction:
ProductivityVSStress or pressure

Solution Approach 1:

The vibration element creates turbulent flow that enhances mixing efficiency without requiring reduced channel depth. This allows the micro flow channel to maintain sufficient depth for acceptable fluid sending pressure while still achieving effective contact between the tested chemical and reactant through vibration-induced turbulence.

Inventive Principle:
Principle #18Mechanical vibration

3Stress or pressure

If the flow rate is reduced to prevent excessive pressure rise, then the fluid moves in laminar flow, but the tested chemical does not blend in the tested fluid even when reciprocated

Engineering Contradiction:
Improvefluid sending pressureVSAvoidlaminar flow
Core Design Contradiction:
Stress or pressureVSStability of the object's composition

Solution Approach 1:

The vibration element transforms the laminar flow caused by low flow rate into turbulent flow, enabling effective mixing of the tested chemical with the tested fluid. This allows the system to maintain low flow rates for acceptable pressure while achieving turbulent mixing through vibration-induced flow instability.

Inventive Principle:
Principle #18Mechanical vibration

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The method significantly improves the reaction efficiency by ensuring that antigens in the tested fluid react more effectively with antibodies, even in conventional-sized micro flow channels, by promoting turbulent-like mixing without increasing pressure or channel depth.

Implementation Method 1

The method significantly improves the reaction efficiency by ensuring that antigens in the tested fluid react more effectively with antibodies, even in conventional-sized micro flow channels, by promoting turbulent-like mixing without increasing pressure or channel depth.

Methodology Applied
Scientific EffectTurbulence: Turbulence

Implementation Method 2

In such a fluid sending system, the fluid moves in laminar flow because Reynolds number is low. Accordingly, even by reciprocating a tested fluid in the fluid sending system, a tested chemical does not blend in the tested fluid

Methodology Applied
Scientific EffectLaminar flow: Laminar Flow

Data Source

PatentUS11249076B2Test device, reaction apparatus and reactive test method
Publication Date: 2022.02.15 OTSUKA PHARM CO LTD
  • US11249076B2 patent drawing
  • US11249076B2 patent drawing
  • US11249076B2 patent drawing

AI summary

A test device having a micro flow channel including a reaction part where a reactant that is reactive to a tested chemical dispersed in a tested fluid is fixed, and at least one actuator for actuating the tested fluid to move in at least one of two opposite sides of the micro flow channel so as to homogenize a density distribution of the tested chemical in the tested fluid. The tested fluid is sent in the micro flow channel a plurality of times.