Micro-magnetophoretic Circuit for Single Biomaterial Manipulation
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Solution Overview
Problem
Current laboratory systems face challenges in efficiently processing large amounts of bio-information, particularly in microfluidics, due to limitations in controlling the translocation and separation of biomolecules at the nano-scale, and existing magnetic systems are costly, difficult to manufacture, and generate heat, while lacking the ability to smoothly transport and trap individual cells or biomaterials.
Innovation Solution
A micro-magnetophoretic circuit and magnetic structure device using soft magnetic microstructures with half-disc and segment patterns, capable of transporting, trapping, and releasing biomaterials by manipulating magnetic fields, allowing for precise control of magnetic structures and biomolecules along patterned circuitry, analogous to electronic circuits, using principles of Ohm's law and non-linear dynamic phenomena.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional magnetic systems are used for biomolecule translocation, then magnetic particles can be manipulated, but the systems are costly, difficult to manufacture, and generate heat
Solution Approach 1:
The patent replaces conventional electromagnet systems with a magnetophoretic circuit system that uses patterned magnetic structures (half-disc and segment patterns) on a substrate. This substitution eliminates the need for complex electromagnet assemblies, reducing manufacturing difficulty and cost while avoiding heat generation from electromagnetic coils. The magnetic field is generated through the patterned structures themselves rather than external electromagnets.
Solution Approach 2:
The patent changes the physical state and distribution of magnetic field generation from centralized electromagnets to distributed patterned magnetic structures. By altering the magnetic field parameters through the half-disc and segment patterns, the system achieves precise control of magnetic particles without the thermal and manufacturing issues of conventional systems.
2Reliability
If conventional magnetic systems are used, then magnetic particles can be manipulated, but the systems generate heat that may kill biological individuals
Solution Approach 1:
The patent replaces electromagnet-based magnetic field generation with a magnetophoretic circuit system using patterned magnetic structures. This substitution eliminates the electromagnetic coils that generate harmful heat, providing a thermal-safe environment for biological samples while maintaining magnetic manipulation capability.
3Reliability
If existing magnetic systems are used, then magnetic particles can be manipulated, but they lack the ability to smoothly transport and trap individual cells or biomaterials
Solution Approach 1:
The patent divides the magnetic field generation into segmented patterns (half-disc patterns and segment patterns) arranged in specific sequences. This segmentation allows for precise spatial and temporal control of magnetic fields, enabling smooth transport and trapping of individual cells or biomaterials by creating localized magnetic gradients that guide particle movement along desired paths.
Solution Approach 2:
The patent creates dynamic magnetic field control by sequentially activating different segments of the patterned magnetic structures. This dynamic activation allows the system to smoothly transport and trap magnetic particles at specific locations, providing precise control over particle movement and positioning that static magnetic systems cannot achieve.
4Measurement precision
If planar array types are used for biomolecule detection, then high sensitive detection is achieved, but the characteristic of individual cells cannot be known
Solution Approach 1:
The patent uses segmented magnetic patterns that can be independently controlled, allowing for the analysis of individual cells or biomaterials while maintaining high detection sensitivity. Each segment can be activated to manipulate specific particles, enabling both sensitive detection and individual cell characterization simultaneously.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables efficient and precise control of biomaterial translocation and separation, facilitating research in individual cell differentiation, cancer cell evolution, and cell heterogeneity, while reducing costs and avoiding heat generation, with the ability to selectively transport and trap biomolecules like DNA, proteins, and cells.
Implementation Method 1
a magnetic force generator which generates a magnetic force
Implementation Method 2
capable of transporting, trapping, and releasing biomaterials by manipulating magnetic fields
Implementation Method 3
micro-magnetophoretic circuit and magnetic structure device
Data Source
AI summary
A device for transporting, trapping and escaping a single biomaterial using a magnetic structure, and a method of transporting, trapping and escaping of the single biomaterial using the same are provided, and a method is provided for controlling movement and direction of the single biomaterial including soft magnetic micro structure and magnetic structure in a linear, square storage, apartment type, radial soft magnetic micro structure. Accordingly, the device for transporting, trapping and escaping a single biomaterial and the method for transporting, trapping and escaping single biomaterial using the same can control movement on the lap-on-a-chip with increased precision and ease, by using magnetic force, and thus can be advantageously used in the field of magneto-resistive sensor, or categorization of single cells or biomolecules.