Micro-Nano Sensing Device for Targeted Pathogen Binding
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Solution Overview
Problem
Current therapeutic approaches face challenges in effectively targeting and neutralizing pathogenic entities, such as cancer cells and viruses, due to their ability to develop resistance mechanisms, and there is a need for precise delivery of therapeutics to minimize off-target effects and enhance efficacy.
Innovation Solution
The development of micro-nano sensing-deciding-effecting devices (MNSDEDs) that utilize logic circuitry and targeting agents to specifically bind to pathogenic entities, activate effector mechanisms, and deliver therapeutic agents, while minimizing resistance development and off-target toxicity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional therapeutics are used to target pathogenic entities, then treatment coverage is achieved, but pathogenic resistance develops rendering therapeutics ineffective
Solution Approach 1:
The patent replaces biological/chemical therapeutic mechanisms with a physical micro-nano device system that uses mechanical binding through targeting agents and logical decision-making circuitry. This non-biomimetic approach eliminates the evolutionary arms race between pathogens and therapeutics, as the device cannot be replicated or adapted by biological evolution.
Solution Approach 2:
The micro-nano device autonomously senses its environment through integrated sensors, makes decisions through logic circuitry, and executes therapeutic actions without external intervention. This self-service capability allows the device to adapt to resistant pathogenic entities dynamically, overcoming resistance mechanisms that render conventional static therapeutics ineffective.
2Adaptability or versatility
If broad-spectrum therapeutics are used to treat pathogenic entities, then treatment coverage is improved, but off-target effects and toxicity increase
Solution Approach 1:
The patent implements local quality through spatially-specific targeting agents that bind only to pathogenic entities with distinct surface markers. The micro-nano device concentrates therapeutic action at the precise location of the target, delivering high concentrations of therapeutic agents only where needed while sparing healthy tissues from exposure and toxicity.
Solution Approach 2:
The therapeutic system is segmented into multiple independent micro-nano devices, each capable of autonomous operation. This segmentation allows parallel treatment of multiple pathogenic entities simultaneously with different targeting specificities, achieving broad coverage without compromising the precision and safety of individual treatment sites.
3Object-affected harmful factors
If precise targeting is achieved using conventional methods, then off-target effects are reduced, but delivery precision to resistant pathogenic entities remains insufficient
Solution Approach 1:
The patent replaces conventional chemical or biological targeting mechanisms with a physically-based micro-nano device system. The device uses integrated sensors to detect pathogenic entities and logic circuitry to process this information, enabling precise delivery control that overcomes the limitations of passive conventional targeting methods.
Solution Approach 2:
The micro-nano device incorporates sensors that continuously monitor the local environment and provide feedback to the logic circuitry. This feedback mechanism allows the device to adjust its behavior in real-time, optimizing delivery precision to resistant pathogenic entities while avoiding off-target effects through dynamic response to environmental conditions.
Data Source
AI summary
A micro-nano sensing device for sensing a chemical, biological, or biochemical entity includes a non-conductive housing having a surface and that contains supporting logic circuitry, signaling circuitry electrically connected to the logic circuitry, and at least one electrically conductive pad positioned on the housing surface and electrically connected to the logic circuitry and to a targeting agent capable of interacting with a target.