Micro-Nano Stent for Directional Drug Release
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Solution Overview
Problem
Conventional nanofiber stents prepared by electrospinning technology cannot achieve directional, quantitative, and timed release of drugs, lacking effective physical structure guidance for cell proliferation and attachment, and controllable drug release mechanisms.
Innovation Solution
A micro-nano medical stent is developed using a combination of coaxial electrospinning and near-field direct writing technologies, featuring a drug-loadable micron ordered electrospun fiber structure as a skeleton layer and a drug-loadable core-shell nano disordered electrospun fiber structure as an ECM layer, which are staggered stacked to form a composite electrospun layer for directional, quantitative, and timed drug release.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of manufacture
If conventional disordered electrospinning technology is used, then nanofiber films can be obtained as drug carriers, but directional release of drugs cannot be achieved and cell proliferation guidance is ineffective
Solution Approach 1:
The patent divides the nanofiber structure into ordered segments with specific spatial arrangements. The electrospun fibers are organized into patterns (e.g., parallel, grid, or radial arrangements) that provide directional cues for drug release and cell growth, transforming the conventional disordered structure into a segmented ordered architecture that maintains manufacturing feasibility while achieving directional control
Solution Approach 2:
The patent modifies key parameters of the electrospinning process to achieve ordered structures. By controlling parameters such as collector rotation speed, voltage, distance, and solution flow rate, the system transitions from producing disordered nanofibers to ordered nanofiber arrays with controlled orientation and spacing, enabling directional drug release while maintaining the electrospinning manufacturing method
2Productivity
If conventional electrospinning is used, then drug-loaded nanofiber films can be produced, but timed release of drugs cannot be achieved
Solution Approach 1:
The patent segments the drug loading and release mechanism by incorporating multiple drug types with different release kinetics into the nanofiber structure. Different drugs are loaded at different concentrations and positions within the ordered nanofiber array, enabling sequential and timed release patterns while maintaining high production efficiency through a single electrospinning process
Solution Approach 2:
The ordered nanofiber structure enables periodic drug release patterns through its organized architecture. The regular spacing and orientation of fibers create controlled diffusion pathways that facilitate rhythmic or staged drug release, allowing timed delivery schedules to be achieved while preserving the efficiency of the electrospinning manufacturing process
3Quantity of substance
If disordered nanofiber structure is used, then drug encapsulation is achieved, but physical structure guidance signals for cell proliferation are insufficient
Solution Approach 1:
The patent applies local quality by creating regions within the nanofiber structure that have different properties. The ordered arrangement provides specific local zones with defined fiber orientation, spacing, and density that offer mechanical guidance cues to cells, while other regions maintain high drug loading capacity. This spatial variation in structure quality enables both drug encapsulation and directional cell guidance
Solution Approach 2:
The patent creates a composite nanofiber structure that combines ordered architectural features with drug-loaded functional materials. The ordered nanofiber matrix serves as both a structural framework providing mechanical guidance signals and a drug carrier, forming a composite system that simultaneously achieves cell proliferation guidance and drug encapsulation through the integration of structural and functional properties
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The stent achieves directional cell adhesion and controlled drug release, with the micron ordered fibers guiding cell attachment and degrading to release drugs, while the core-shell nano disordered fibers ensure sequential and timed drug release, addressing the limitations of conventional nanofiber stents.
Implementation Method 1
By achieving jet ejection and drawing through applying a high-voltage electric field on the syringe filled with a spinning solution or a spinning melt and a conductive collection plate
Implementation Method 2
By achieving jet ejection and drawing through applying a high-voltage electric field on the syringe filled with a spinning solution or a spinning melt
Data Source
AI summary
The present disclosure belongs to the technical field of drug delivery and biomimetic structures inducing cell proliferation and differentiation, and in particular relates to a micro-nano medical stent for directional, quantitative and timed controlled release of drug and a preparation method thereof. The micro-nano medical stent provided by the present disclosure is composed of an ordered fiber structure electrospun as a skeleton layer and a disordered fiber structure electrospun as an ECM layer that can both load drugs. The micro-nano medical stent can achieve directional, quantitative and timed release of drugs.