Micro-nanobubble Oxygen Delivery for Chronic Wound Healing
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Chronic non-healing wounds, particularly in the elderly, face challenges with maintaining appropriate oxygen levels due to local tissue hypoxia, which impairs wound healing and is exacerbated by conditions like diabetes and peripheral vascular disease.
Innovation Solution
An apparatus and method utilizing micro-nanobubbles (MNBs) for delivering oxygen to tissues, combining with negative pressure wound therapy (NPWT) to enhance oxygenation and promote wound healing, involving a system with a liquid source, gas source, micro-nanobubble generation pump, decompression nozzle, and treatment applicator for targeted oxygen delivery.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If room air diffusion is used for oxygen delivery, then the system is simple and requires no additional equipment, but the oxygen partial pressure (160 mmHg) is insufficient to reduce infection and promote wound healing
Solution Approach 1:
The patent introduces micro-nanobubbles as an intermediary carrier to transport oxygen from the liquid solution to the wound tissue. The bubbles act as a mediator that overcomes the limitation of direct air diffusion, delivering oxygen at required partial pressures without requiring complex hyperbaric equipment
Solution Approach 2:
The patent changes the physical state of oxygen delivery from gaseous diffusion (room air) to dissolved gas in liquid solution containing micro-nanobubbles. This parameter change enables oxygen delivery at higher partial pressures (80-300 mmHg) while maintaining a simple topical application system
2Quantity of substance
If supplemental oxygen is applied to increase oxygen partial pressure to reduce infection, then oxygenation improves, but the complexity of delivering oxygenated liquid increases
Solution Approach 1:
The system uses a simple liquid source and gas source that automatically mix to create oxygen-enriched solution with micro-nanobubbles. The apparatus performs self-service by generating the oxygen-carrying bubbles in-situ without requiring external oxygen tanks or complex delivery infrastructure
Solution Approach 2:
The patent uses pneumatic principles by introducing gas into liquid to create micro-nanobubbles that carry oxygen to the wound. This hydraulic-pneumatic approach simplifies the system by using fluid dynamics rather than mechanical compression or complex delivery mechanisms
3Quantity of substance
If micro-nanobubbles are used for oxygen delivery, then oxygen tension in wounds increases significantly, but the apparatus complexity increases with multiple components
Solution Approach 1:
The patent divides the oxygen delivery function into separate modular components: liquid source, gas source, mixing chamber, and application device. This segmentation allows each component to be simple and independently replaceable, reducing overall system complexity while achieving high oxygen tension delivery through the micro-nanobubble mechanism
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The MNB-based system significantly increases oxygen tension in wounds, improving wound healing by enhancing oxygen delivery and promoting tissue oxygenation, thereby aiding in the treatment of chronic non-healing ulcers and impaired healing processes.
Implementation Method 1
passing the gas/liquid mixture through a decompression nozzle to generate micro-nanobubbles in the gas/liquid mixture
Implementation Method 2
Nanobubbles have several unique properties... They can form freely and remain in an aqueous solution for extended periods of time with the capacity to act as a reservoir and store oxygen
Data Source
AI summary
The invention provides an apparatus for the generation and administration of a micro-nanobubble solution to a tissue, a method for the treatment of a tissue with a solution of micro-nanobubbles, and a kit for the treatment of tissue with micro-nanobubbles.