Micro-Metal Tube Guided-Wave Thrombus Elasticity Sensing

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Solution Overview

Problem

Existing thrombus elasticity measurement devices require a large amount of blood and have poor real-time performance due to complex excitation methods and high production costs, leading to measurement errors and inability to detect dynamic changes in blood viscosity.

Innovation Solution

A micro-metal tube thrombus elasticity detection device utilizing an L(0, 1) longitudinal mode guided wave, which includes a micro-metal tube, a magnetostrictive assembly, and a data processing module to measure thrombus elasticity by correlating energy attenuation with liquid viscosity, enabling real-time detection with a small blood sample.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Quantity of substance

If traditional thrombus elasticity measurement devices (Sonoclot, TEG, ROTEM) are used, then thrombus elasticity can be measured, but a large amount of blood (1 ml or more) and long detection time (over 1 hour) are required

Engineering Contradiction:
Improveblood sample volumeVSAvoiddetection speed
Core Design Contradiction:
Quantity of substanceVSProductivity

Solution Approach 1:

The patent replaces traditional mechanical/probe-based measurement systems with a micro-metal tube ultrasonic guided wave system. The micro-metal tube serves as both the measurement chamber and the waveguide, eliminating the need for large blood volumes while enabling rapid detection through ultrasonic wave propagation and attenuation measurement.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The patent changes the detection parameter from traditional probe-based mechanical measurement to ultrasonic guided wave attenuation measurement. By measuring the attenuation of ultrasonic waves in the micro-metal tube filled with blood, the system achieves rapid thrombus elasticity measurement with minimal blood sample volume.

Inventive Principle:
Principle #35Parameter changes

2Reliability

If complex excitation methods (spraying magnetostrictive powder or installing strips on micro-metal tube) are used, then ultrasonic guided wave can be generated, but production cost increases and magnetic field distribution becomes uneven causing measurement errors

Engineering Contradiction:
Improvemeasurement accuracyVSAvoidexcitation method complexity
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

The patent extracts the magnetostrictive material from the micro-metal tube structure and places it in a separate excitation assembly. This separates the excitation function from the measurement chamber, simplifying the micro-metal tube design while ensuring uniform magnetic field distribution through the dedicated excitation assembly with optimized magnet and coil configuration.

Inventive Principle:
Principle #2Taking out (Extraction)

Solution Approach 2:

The patent introduces a dedicated excitation assembly as an intermediary component between the power source and the micro-metal tube. This assembly includes optimized magnet and coil configurations that generate uniform magnetic field distribution, acting as a mediator to ensure consistent ultrasonic wave generation without direct modification of the micro-metal tube structure.

Inventive Principle:
Principle #24Intermediary (Mediator)

3Ease of operation

If traditional excitation methods are used, then ultrasonic wave can be generated, but sensor technology requirements are high and practical application is difficult

Engineering Contradiction:
Improvepractical applicabilityVSAvoidsensor technology requirement
Core Design Contradiction:
Ease of operationVSDevice complexity

Solution Approach 1:

The micro-metal tube itself serves dual purposes: as the measurement chamber containing blood and as the waveguide for ultrasonic waves. The excitation assembly generates waves that propagate through the micro-metal tube walls, eliminating the need for complex external sensor systems and simplifying practical application while maintaining measurement accuracy.

Inventive Principle:
Principle #25Self-service

4Productivity

If static blood viscosity measurement is performed, then viscosity value can be obtained, but dynamic thrombus elasticity measurement and time-dependent analysis cannot be achieved

Engineering Contradiction:
Improvemeasurement speedVSAvoiddynamic change information
Core Design Contradiction:
ProductivityVSLoss of information

Solution Approach 1:

The patent implements continuous ultrasonic wave propagation and attenuation measurement throughout the thrombus formation process. The system continuously monitors changes in wave attenuation over time, enabling real-time detection of dynamic thrombus elasticity changes and providing complete time-dependent analysis of coagulation processes.

Inventive Principle:
Principle #20Continuity of useful action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The device achieves accurate and real-time thrombus elasticity measurement with a small blood sample, overcoming the limitations of traditional devices by providing high integration, portability, and rapid results, allowing for on-site use.

Implementation Method 1

A micro-metal tube thrombus elasticity detection device based on an L(0, 1) longitudinal mode guided wave includes a device housing, a micro-metal tube, and a magnetostrictive assembly

Methodology Applied
Scientific EffectMagnetostriction: Magnetostriction

Implementation Method 2

The invention utilizes the correlation between the propagation attenuation of a longitudinal ultrasonic guided wave in a micro-metal tube and liquid viscosity

Methodology Applied
Scientific EffectUltrasonic guided wave propagation: Ultrasound

Data Source

PatentUS12487161B2Micro-metal tube thrombus elasticity detection device and method based on L(0,1) longitudinal mode guided wave
Publication Date: 2025.12.02 ZHEJIANG UNIV
  • US12487161B2 patent drawing
  • US12487161B2 patent drawing
  • US12487161B2 patent drawing

AI summary

The invention discloses a micro-metal tube thrombus elasticity detection device and method based on an L(0,1) longitudinal mode guided wave. The device includes a device housing, a temperature control module, a micro-metal tube, and a magnetostrictive assembly. The housing is externally connected to the temperature control module to realize internal constant temperature, the replaceable micro-metal tube is installed inside, the magnetostrictive assembly composed of a permanent magnet and a coil is provided at one end outside the tube. An L(0,1) longitudinal mode guided wave is excited on the micro-metal tube. When liquid viscosity within the tube changes, the energy attenuation of the guided wave propagating along the tube is different. The energy attenuation of the guided wave is defined through the attenuation rate of multiple echo peak values to reflect changes in the blood viscosity.