Microbe Composition for Metabolic Syndrome Therapy

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Solution Overview

Problem

Current methods for treating metabolic syndrome, such as antibiotics, fail to provide long-term solutions and can lead to bacterial resistance, while lifestyle changes are difficult to maintain, making it challenging to effectively manage the condition.

Innovation Solution

Administering a microbe composition containing bacteria from genus AF12, Helicobacter, or Odoribacter, derived from donors with regular exercise and non-high-fat diets, to modulate blood glucose, inhibit weight gain, and reduce inflammatory factors in the gastrointestinal tract.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If antibiotics are used to treat gastrointestinal microbiota abnormalities, then symptoms can be improved, but the therapeutic effect cannot be maintained after drug withdrawal and bacterial resistance may develop

Engineering Contradiction:

Improvetherapeutic effectVSAvoidbacterial resistance

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent introduces probiotics (beneficial bacteria) to counteract the harmful effects of antibiotics and restore intestinal flora balance. By administering live microorganisms that colonize the gut, the therapy converts the harmful disruption caused by antibiotics into a beneficial restoration of microbial equilibrium, preventing resistance while maintaining therapeutic effects

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

Solution Approach 2:

The patent uses probiotics as an intermediary substance to mediate between the host and the disrupted microbiota. These live microorganisms act as intermediaries that restore ecological balance in the gut, providing a sustainable therapeutic mechanism that does not rely on continuous antibiotic administration and avoids resistance development

Inventive Principle:

Principle #24Intermediary (Mediator)

2Reliability

If lifestyle changes (exercise and diet) are implemented to improve metabolic syndrome, then health can be improved, but most people cannot maintain good lifestyle habits

Engineering Contradiction:

Improvehealth improvementVSAvoidmaintenance period

Core Design Contradiction:

ReliabilityVSDuration of action of stationary object

Solution Approach 1:

The patent employs probiotics that autonomously colonize the gastrointestinal tract and continuously perform metabolic functions without requiring external intervention. These microorganisms self-maintain and persist in the host, providing ongoing therapeutic effects for metabolic syndrome management without depending on the host's ability to maintain lifestyle changes

Inventive Principle:

Principle #25Self-service

Solution Approach 2:

The patent introduces beneficial microorganisms in advance that establish themselves in the gut before metabolic issues fully develop or worsen. These pre-established probiotics create a protective microbial environment that proactively manages metabolic health, preventing the need for continuous lifestyle monitoring and adjustment

Inventive Principle:

Principle #10Preliminary action

Data Source

PatentUS10441612B2Intestinal microbe therapy, composition therefor and method for preparing the same

Publication Date: 2019.10.15 TAICHUNG VETERANS GENERAL HOSPITAL

AI summary

The present invention discloses a method for treating and/or preventing metabolic syndrome and related diseases thereof, by administering a microbe composition to an individual to achieve the modulation of blood glucose, inhibition of body weight gain, reduction of low density cholesterol in blood, and reduction of hepatic expression of inflammatory factors, thereby effectively treating and/or preventing metabolic syndrome or related diseases thereof.