Defined Microbial Compositions for Aging-Related Immune Modulation

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Solution Overview

Problem

There is a lack of understanding of how probiotics modulate the immune system and a need for effective strategies to prevent and manage aging-associated inflammation, particularly due to low-grade chronic inflammation, which is not well addressed by current commercial probiotics.

Innovation Solution

Pharmaceutical compositions comprising specific microbial entities with defined 16S rDNA or 18S rDNA sequences, functional expression sequences, or metabolic signatures, delivered via pharmaceutically acceptable vehicles, to target and modulate the immune system.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If commercial probiotics are used, then immune system modulation is attempted, but the effectiveness is insufficient and the mechanisms are not well understood

Engineering Contradiction:

Improveeffectiveness of immune modulationVSAvoidunderstanding of probiotic mechanisms

Core Design Contradiction:

ReliabilityVSLoss of information

Solution Approach 1:

The patent segments the probiotic concept into specific defined microbial entities with identified 16S rDNA or 18S rDNA sequences, functional expression sequences, or metabolic signatures. This segmentation allows for precise characterization and selection of probiotic strains, moving from general commercial probiotics to specifically defined microbial entities with known mechanisms of action.

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

The patent changes the parameters for defining probiotics from commercial formulations to specific molecular characteristics (16S rDNA sequences, 18S rDNA sequences, functional expression sequences, metabolic signatures). This parameter change enables precise identification and selection of probiotic entities with proven immune modulating capabilities.

Inventive Principle:

Principle #35Parameter changes

2Reliability

If plant-based diets are consumed, then health benefits are achieved, but the mechanistic association with microbial benefits is unclear

Engineering Contradiction:

Improvehealth benefitsVSAvoidmechanistic association

Core Design Contradiction:

ReliabilityVSLoss of information

Solution Approach 1:

The patent identifies specific microbial entities as intermediaries between plant-based diet consumption and health benefits. These defined probiotic strains serve as the mechanistic link, transforming the vague association into a concrete biological mechanism where specific microbes mediate the health effects of plant-based nutrition.

Inventive Principle:

Principle #24Intermediary (Mediator)

3Reliability

If aging population is considered, then inflammaging is observed, but effective prevention strategies are lacking

Engineering Contradiction:

Improvemanagement of inflammagingVSAvoidavailability of prevention strategies

Core Design Contradiction:

ReliabilityVSAdaptability or versatility

Solution Approach 1:

The patent defines microbial entities with multi-functional capabilities including immune modulation, anti-inflammatory effects, and potential applications across multiple aging-related conditions. These universally applicable probiotic strains can address various aspects of inflammaging and aging-related diseases, providing versatile prevention strategies.

Inventive Principle:

Principle #6Universality (Multi-functionality)

Data Source

PatentUS20250367246A1Immunomodulatory compositions comprising microbial entities

Publication Date: 2025.12.04 SOLAREA BIO INC

AI summary

This disclosure provides for compositions (e.g., pharmaceutical compositions, dietary supplements, medical foods and food stuff), comprising combinations of live microbe populations for the treatment and/or prevention of immune system disorders and conditions related to inflammation, including both pathogen assisted conditions and conditions that are independent of pathogens. Included with the present disclosure are methods for use of the compositions, and methods for selecting microbial entities to formulate the compositions of the disclosure.