Microbial Oil Composition for High-Retinoid Fermentation Production
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Solution Overview
Problem
Conventional methods for producing retinoids face challenges in achieving high concentrations due to complex purification steps and by-product production, and chemically synthesized retinoids are expensive with fluctuating prices, making it difficult to produce stable and economical products.
Innovation Solution
A microbial oil composition comprising retinoids and fatty acids is developed, with retinoids present in amounts ranging from 30% to 100% by weight, produced through microbial fermentation using genetically modified microorganisms like Yarrowia lipolytica, enhanced with genetic modifications to enhance retinoid production.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If chemical synthesis is used to produce retinoids, then retinoid production is achieved, but production cost increases and price stability deteriorates due to expensive and fluctuating raw materials
Solution Approach 1:
The patent changes the production method from chemical synthesis to microbial fermentation, fundamentally altering the manufacturing process parameters. This substitution eliminates dependence on expensive chemical raw materials and introduces a more stable, cost-effective production system using microorganisms to synthesize retinoids
Solution Approach 2:
The patent replaces the chemical synthesis mechanism with a biological fermentation mechanism. Instead of using chemical reactions and reagents, the invention employs microbial metabolic pathways to produce retinoids, thereby reducing production costs and improving price stability
2Quantity of substance
If chemical synthesis is used to produce retinoids, then retinoid production is achieved, but process complexity increases due to complex purification steps and byproduct production
Solution Approach 1:
The patent extracts and eliminates the complex purification steps and byproduct management requirements from the production process. By using microbial fermentation, the method naturally produces retinoids with fewer impurities, thereby simplifying the overall process and removing the need for complex purification equipment and procedures
Solution Approach 2:
The patent converts the potential harm of byproduct production into a benefit by using microbial fermentation, which naturally produces retinoids with high purity and minimal byproducts. This approach transforms a complex purification problem into a simplified production process where the microbial system inherently generates the desired product with fewer contaminants
3Quantity of substance
If conventional methods are used to produce retinoids, then retinoid production is achieved, but retinoid concentration remains low
Solution Approach 1:
The patent changes the fundamental production parameters by switching from chemical synthesis to microbial fermentation. This parameter change enables significantly higher retinoid concentrations in the final product, as the microbial system can be optimized for high-yield retinoid production, thereby improving both concentration and overall productivity
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The microbial oil composition achieves high retinoid content, providing a stable and economical alternative for cosmetic, food, and feed applications, overcoming the limitations of chemical synthesis.
Implementation Method 1
produced through microbial fermentation using genetically modified microorganisms like Yarrowia lipolytica
Data Source
AI summary
The present disclosure relates to a microbial oil composition comprising retinoids and fatty acids; a cosmetic composition comprising the microbial oil composition; a food composition comprising the microbial oil composition; a feed composition comprising the microbial oil composition; and a preparation method thereof.