Microbial Nutritive Polypeptides for Balanced Amino Acid Delivery

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Solution Overview

Problem

Existing protein sources, particularly plant-based proteins, often lack the necessary balance of essential amino acids and are associated with allergenicity issues, leading to inefficiencies in meeting nutritional requirements and environmental concerns with animal protein sources.

Innovation Solution

Development of nutritive polypeptides with enhanced solubility and stability, derived from microorganisms, which can be formulated into liquid or semi-liquid nutritional formulations, providing a balanced amino acid profile without non-comestible products.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Object-affected harmful factors

If plant-based proteins are used as dietary protein sources, then environmental impact is reduced and allergenicity issues are minimized, but the balance of essential amino acids is insufficient

Engineering Contradiction:

ImproveallergenicityVSAvoidessential amino acid balance

Core Design Contradiction:

Object-affected harmful factorsVSQuantity of substance

Solution Approach 1:

The patent modifies the amino acid composition parameters of plant-based proteins through selective breeding and genetic engineering to enhance essential amino acid content while maintaining the low-allergenicity characteristics of plant sources

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent creates composite protein products by combining multiple plant protein sources with complementary amino acid profiles to achieve a balanced essential amino acid composition while maintaining environmental sustainability and reduced allergenicity

Inventive Principle:

Principle #40Composite materials

2Quantity of substance

If animal protein sources are used to provide high quality protein, then essential amino acid balance is improved, but environmental impact increases

Engineering Contradiction:

Improveessential amino acid balanceVSAvoidenvironmental impact

Core Design Contradiction:

Quantity of substanceVSObject-affected harmful factors

Solution Approach 1:

The patent changes the production method from animal-based to microorganism-based protein synthesis, maintaining high essential amino acid balance while eliminating the environmental burdens associated with animal agriculture

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent uses microorganisms to copy and produce animal protein sequences in a controlled, sustainable manner, achieving the same nutritional quality without the environmental cost of animal farming

Inventive Principle:

Principle #26Copying

3Quantity of substance

If free amino acids and hydrolyzed proteins are used in nutritional formulations, then amino acid availability is improved, but taste and solubility deteriorate

Engineering Contradiction:

Improveamino acid availabilityVSAvoidsolubility and taste

Core Design Contradiction:

Quantity of substanceVSEase of operation

Solution Approach 1:

The patent optimizes the molecular weight distribution and physicochemical parameters of the polypeptide fractions to achieve optimal solubility and taste characteristics while maintaining amino acid availability

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent creates polypeptide fractions with different average molecular weights, each having specific local quality characteristics that provide both solubility and amino acid availability, allowing selective use in different formulation contexts

Inventive Principle:

Principle #3Local quality

Data Source

PatentUS20260069656A1Nutritive Polypeptides and Formulations Thereof, and Methods of Production and Use Thereof

Publication Date: 2026.03.12 AXCELLA (ASSIGNMENT FOR THE BENEFIT OF CREDITORS) LLC

AI summary

Nutritive Polypeptides are provided herein. Also provided are various other embodiments including nucleic acids encoding the polypeptides, recombinant microorganisms that make the polypeptides, vectors for expressing the polypeptides, methods of making the polypeptides using recombinant microorganisms, compositions and formulations that comprise the polypeptides, and methods of using the polypeptides, compositions and formulations.