Synergistic Microbicidal Composition for Resistant Strains
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Solution Overview
Problem
Commercial microbicides often fail to provide effective control of microorganisms, especially resistant strains and in aggressive environmental conditions, necessitating the development of synergistic combinations for enhanced activity at lower concentrations for economic and environmental benefits.
Innovation Solution
A microbicidal composition comprising 1,2-benzisothiazolin-3-one and various microbicides such as benzalkonium chloride, benzethonium chloride, or 2-methyl-4-isothiazolin-3-one with caprylyl glycol, which together exhibit enhanced efficacy at lower combined active ingredient levels, providing effective control of microorganisms.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If higher concentrations of individual microbicides are used, then microbicidal activity is improved, but environmental harm and cost increase
Solution Approach 1:
The patent combines multiple microbicides (1,2-benzisothiazolin-3-one with benzalkonium chloride, benzethonium chloride, or 2-methyl-4-isothiazolin-3-one with caprylyl glycol) to create synergistic formulations. This merging of substances achieves enhanced microbicidal activity at lower overall concentrations, thereby maintaining effectiveness while reducing environmental harm and cost associated with using high concentrations of single microbicides.
2Reliability
If higher concentrations of individual microbicides are used, then microbicidal activity is improved, but cost increases
Solution Approach 1:
The patent combines multiple microbicides to create synergistic formulations that achieve enhanced microbicidal activity at lower overall concentrations. This merging approach reduces the total quantity of active ingredients needed, thereby lowering cost while maintaining or improving microbicidal activity compared to using higher concentrations of single microbicides.
3Device complexity
If single microbicides are used, then formulation simplicity is maintained, but effectiveness against resistant strains decreases
Solution Approach 1:
The patent combines multiple microbicides with different mechanisms of action to create formulations that are effective against resistant microbial strains. The synergistic combination of 1,2-benzisothiazolin-3-one with benzalkonium chloride or benzethonium chloride, and 2-methyl-4-isothiazolin-3-one with caprylyl glycol, provides broad-spectrum activity that overcomes resistance while maintaining reasonable formulation simplicity.
Data Source
AI summary
A microbicidal composition of 1,2-benzisothiazolin-3-one; and at least one of benzalkonium chloride, benzethonium chloride, benzyl alcohol, caprylyl glycol, chlorphenesin, diazolidinyl urea, ethylparaben, imidazolidinyl urea, methylparaben, phenoxyethanol, linoleamidopropyl PG-dimonium chloride phosphate, cocamidopropyl PG-dimonium chloride phosphate, propylparaben, cis-1-(3-chloroallyl)-3,5,7-triaza-1-azoniaadamantane chloride, dehydroacetic acid or its salts, benzoic acid or its salts, and sodium hydroxymethylglycinate.