Microbicidal Composition Synergy Halogen Removal
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Commercial microbicides often fail to provide effective and long-lasting control over microorganisms, especially resistant strains, even at high concentrations, necessitating the development of additional combinations with enhanced activity.
Innovation Solution
A microbicidal composition comprising a non-halogenated 2-alkyl-4-isothiazolin-3-one combined with 2,2′-dithiobis(N-methylbenzamide) or 2-methylbenzisothiazolone, offering synergistic efficacy at lower combined active ingredient levels without the need for halogenated 3-isothiazolone, which avoids chemical degradation and stabilizer-related issues.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If halogenated 3-isothiazolone is used to achieve microbicidal activity, then microbicidal efficacy is improved, but chemical degradation occurs and stabilizer requirements increase complexity
Solution Approach 1:
The patent extracts the halogen atom from the 3-isothiazolone structure, replacing it with a hydrogen atom to create a non-halogenated derivative. This removal of the halogen group eliminates the chemical degradation pathway and stabilizer requirements while preserving the core microbicidal activity through combination with other agents
Solution Approach 2:
The patent combines non-halogenated 3-isothiazolone with isothiazolinone to create a composite microbicidal system. This composite approach allows the non-halogenated compound to provide stability and long-acting properties while the isothiazolinone component provides rapid microbicidal activity, achieving both efficacy and stability
2Reliability
If high concentrations of single microbicide are used to control resistant microorganisms, then microbicidal activity is improved, but the risk of chemical degradation and stabilizer requirements increases
Solution Approach 1:
The patent segments the microbicidal function into two distinct components: non-halogenated 3-isothiazolone for stability and long-acting control, and isothiazolinone for rapid activity. This segmentation allows each component to be optimized for its specific function, achieving effective control of resistant microorganisms without requiring high concentrations of a single unstable agent
Solution Approach 2:
The patent merges non-halogenated 3-isothiazolone and isothiazolinone into a single synergistic formulation. The combination produces enhanced microbicidal activity against resistant strains while the non-halogenated component provides formulation stability, eliminating the need for separate stabilizer systems
3Stability of the object's composition
If non-halogenated 3-isothiazolone is used alone, then chemical stability is improved, but microbicidal activity against resistant strains is insufficient
Solution Approach 1:
The patent changes the chemical parameter of the isothiazolone compound by removing the halogen substitution, transforming it from a highly active but unstable halogenated form to a stable non-halogenated form. This parameter change is then combined with another active agent to restore and enhance microbicidal activity while maintaining the stability benefit
Data Source
AI summary
A microbicidal composition containing: (a) at least one non-halogenated 2-alkyl-4-isothiazolin-3-one selected from substituted and unsubstituted 2-(C1-C4)alkyl-4-isothiazolin-3-ones; and (b) at least one of 2,2′-dithiobis(N-methylbenzamide) and 2-methylbenzisothiazolone.