Microbiome Regulators Modulating Gut Microbiota
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Solution Overview
Problem
Current probiotic and prebiotic treatments have modest effects on human health and are associated with conflicting clinical results, indicating a need for novel therapeutics that can effectively stimulate beneficial microbiota shifts and improve human health.
Innovation Solution
Development of compounds and compositions comprising microbiome regulators, such as sugars, sugar alcohols, amino acids, peptides, micronutrients, fatty acids, and polyphenols, designed to target the gastrointestinal tract for controlled release, promoting specific bacterial growth and modulating the gut microbiota.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional probiotic and prebiotic treatments are used, then some health benefits are achieved, but the effects are modest and clinical results are conflicting
Solution Approach 1:
The patent applies parameter changes by modifying the chemical structure of sugar molecules to create novel prebiotic compounds with enhanced functionality. Specifically, the invention introduces modified glycosidic bonds and molecular weight adjustments to optimize bacterial recognition and utilization, thereby improving the reliability and efficacy of microbiota modulation compared to conventional prebiotics
Solution Approach 2:
The patent employs composite materials by combining multiple sugar units with specific configurations into complex oligosaccharide structures. These composite sugar molecules are designed to simultaneously support the growth of multiple beneficial bacterial strains, creating a synergistic effect that enhances overall health outcomes and resolves the conflicting results seen with single-component prebiotics
2Adaptability or versatility
If the microbiome regulator comprises complex sugar structures, then beneficial bacterial growth is promoted, but the molecular complexity increases
Solution Approach 1:
The patent applies segmentation by breaking down complex carbohydrate structures into specific oligosaccharide units with defined glycosidic bond configurations. Each unit is designed to be recognized by specific bacterial enzymes, allowing the molecule to be segmented into functional modules that can be metabolized by different bacterial strains, thus promoting broad bacterial growth while maintaining manageable molecular complexity
3Measurement precision
If targeted release in gastrointestinal tract is implemented, then delivery precision is improved, but the dosage form complexity increases
Solution Approach 1:
The patent uses an intermediary approach by employing specific sugar structures that act as mediators between the dosage form and the target bacteria in the gastrointestinal tract. These sugar molecules are designed to resist digestion in the upper GI tract and selectively interact with beneficial bacteria in the colon, achieving targeted delivery through chemical mediation rather than complex physical delivery systems
Data Source
AI summary
Compositions comprising microbiome regulators are provided, as well as methods of using the same for the modulation of the human microbiota and to treat or prevent related diseases, disorders, or conditions.