Microbiome Sequencing Diagnostic System for STD Panel Testing

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Solution Overview

Problem

Current diagnostic testing methods in immunology and microbiology are time-consuming, labor-intensive, and costly, often limited to a few tests, which discourages individuals from undergoing testing due to inefficiencies and patient sensitivity issues.

Innovation Solution

A method and system for comprehensive diagnostic testing that includes providing a sampling kit, sequencing nucleic acid content, detecting microbiome targets associated with STDs, generating diagnostic analyses, and recommending therapies, allowing for simultaneous testing of multiple disease markers and microbiome characteristics.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Loss of information

If comprehensive diagnostic testing for multiple diseases is performed, then diagnostic coverage and information completeness improve, but testing time and operational complexity increase

Engineering Contradiction:

Improvediagnostic information completenessVSAvoidtesting time

Core Design Contradiction:

Loss of informationVSLoss of time

Solution Approach 1:

The patent combines multiple disease panel tests into a single comprehensive diagnostic test that simultaneously analyzes multiple disease markers, microbiome characteristics, and other health parameters from one biological sample, eliminating the need for separate testing procedures

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

The diagnostic system is designed to perform multiple functions including detecting various STDs, analyzing microbiome composition, assessing inflammatory markers, and providing therapeutic recommendations all through a single testing platform and workflow

Inventive Principle:

Principle #6Universality (Multi-functionality)

2Loss of information

If comprehensive diagnostic testing for multiple diseases is performed, then diagnostic coverage improves, but labor intensity and operational complexity increase

Engineering Contradiction:

Improvediagnostic information completenessVSAvoidoperational complexity

Core Design Contradiction:

Loss of informationVSDevice complexity

Solution Approach 1:

The system enables patients to perform sample collection and initiate the diagnostic process independently through automated workflows, with the laboratory system automatically processing samples and generating comprehensive reports without requiring manual coordination of multiple separate tests

Inventive Principle:

Principle #25Self-service

Solution Approach 2:

Multiple disease detection functions are merged into a single integrated testing platform that processes one sample for multiple disease panels simultaneously, reducing the operational steps required compared to performing separate tests

Inventive Principle:

Principle #5Merging (Combining)

3Loss of information

If comprehensive diagnostic testing for multiple diseases is performed, then diagnostic coverage improves, but cost increases

Engineering Contradiction:

Improvediagnostic information completenessVSAvoidtesting cost

Core Design Contradiction:

Loss of informationVSQuantity of substance

Solution Approach 1:

The patent merges multiple separate disease panel tests into a single comprehensive test that shares common reagents, processing steps, and infrastructure, thereby reducing the per-test cost compared to performing multiple separate tests

Inventive Principle:

Principle #5Merging (Combining)

4Speed

If rapid diagnostic testing is implemented, then patient sensitivity and adherence improve, but testing comprehensiveness may be reduced

Engineering Contradiction:

Improvetesting speedVSAvoiddiagnostic information completeness

Core Design Contradiction:

SpeedVSLoss of information

Solution Approach 1:

The system combines rapid sample processing with comprehensive multi-panel analysis, using automated high-throughput methodologies that can analyze multiple disease markers and microbiome parameters simultaneously without requiring sequential testing

Inventive Principle:

Principle #5Merging (Combining)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This approach enables high-throughput, specific, and comprehensive diagnostic testing for multiple STDs and microbiome characterizations, improving efficiency, convenience, and adherence, while providing personalized therapy recommendations.

Implementation Method 1

generating a microbiome composition dataset based upon sequencing nucleic acid content of a microorganism portion of the sample

Methodology Applied

Scientific EffectSequencing:

Data Source

PatentUS10415105B2Method and system for diagnostic testing

Publication Date: 2019.09.17 PSOMAGEN INC

AI summary

An embodiment of a method for diagnostic testing includes: providing a sampling kit to a subject, the sampling kit including a sample container for reception of a sample from a collection site of the subject; receiving the sample from the subject; generating a microbiome sequence dataset based upon sequencing nucleic acid content of a microorganism portion of the sample; detecting a presence of a set of microbiome targets; generating a diagnostic analysis based on the detected set of microbiome targets; generating a therapy recommendation based on the set of microbiome targets; and promoting the therapy recommendation in coordination with presenting information derived from the diagnostic analysis.