Microbiota Co-Culture Composition for Dysbiosis Treatment

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Solution Overview

Problem

There is a need for effective compositions and methods to treat or prevent dysbiosis, obesity, infection, colitis, inflammatory bowel disease, autoimmune diseases, and cancer immunotherapy, as existing treatments fail to adequately address the disrupted microbial balance and its associated health issues.

Innovation Solution

A synthetic composition comprising a co-culture of at least two distinct bacterial families with differing growth and proliferative conditions, having at least 30% similarity to a targeted microbiota population, which includes a combination of aerobic and anaerobic bacteria, and can be administered via various routes to restore healthy microbial balance.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If existing treatments are used for dysbiosis and related disorders, then treatment is provided, but the treatments fail to adequately restore microbial balance

Engineering Contradiction:

Improveeffectiveness of treatmentVSAvoidability to restore microbial balance

Core Design Contradiction:

ReliabilityVSAdaptability or versatility

Solution Approach 1:

The invention segments the microbiota into multiple distinct bacterial families (aerobic and anaerobic) with specific growth conditions, creating a structured composition that targets different aspects of microbial balance restoration rather than using a single undifferentiated treatment approach

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

The invention changes the parameters of the bacterial composition by selecting specific families with differing growth and proliferative conditions, transforming the treatment from conventional single-strain approaches to a multi-parameter composition that better replicates natural microbiota diversity

Inventive Principle:

Principle #35Parameter changes

2Ease of operation

If a single bacterial strain is used for treatment, then the treatment is simple to administer, but it cannot adequately restore complex microbial balance

Engineering Contradiction:

Improvesimplicity of administrationVSAvoidability to restore microbial balance

Core Design Contradiction:

Ease of operationVSAdaptability or versatility

Solution Approach 1:

The invention merges multiple distinct bacterial families into a single composite composition that can be administered together, combining the benefits of diverse microbial strains while maintaining ease of administration as a unified treatment product

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

The composition is designed to perform multiple functions simultaneously - restoring aerobic bacteria, restoring anaerobic bacteria, and providing pathogen resistance through a single multi-functional treatment rather than requiring separate administrations

Inventive Principle:

Principle #6Universality (Multi-functionality)

3Ease of manufacture

If conventional treatments are used for dysbiosis, then treatment is provided, but the disrupted microbial balance and associated health issues are not adequately addressed

Engineering Contradiction:

Improveavailability of treatmentVSAvoideffectiveness in addressing root cause

Core Design Contradiction:

Ease of manufactureVSReliability

Solution Approach 1:

The invention takes preliminary action by proactively restoring both aerobic and anaerobic bacterial populations before pathological conditions fully develop, preventing dysbiosis-related disorders rather than merely treating symptoms after they occur

Inventive Principle:

Principle #10Preliminary action

Data Source

PatentUS11679136B2Composition and methods for microbiota therapy

Publication Date: 2023.06.20 MYBIOTICS PHARMA LTD

AI summary

The present invention provides a composition comprising a co-culture of at least two distinct bacterial families, having differing growth and/or proliferative conditions. In some embodiments, the composition comprises a plurality of bacterial genera with high similarity to microbial flora.