Microbot-Loaded Pharmaceutical Formulations for Targeted Drug Delivery
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Solution Overview
Problem
Traditional therapeutic delivery methods are inefficient for localized delivery, often resulting in adverse side effects, wastage of expensive drugs, and require complex dosing regimens, which can be burdensome for patients, especially those with limited ability to manage their treatment.
Innovation Solution
Pharmaceutical formulations adapted for use on or in microbots, comprising a therapeutically effective dose of a pharmaceutical agent, such as small molecule drugs or biologics, suspended in hydrogel matrices or isotonic lyophilized polyplexes, designed for controlled release at specific locations within the body, reducing the need for frequent administration and improving patient compliance.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Object-affected harmful factors
If traditional delivery means (pills, capsules, injections) are used, then the therapeutic agent can be administered systemically, but the delivery is not localized and causes adverse side effects throughout the body
Solution Approach 1:
The invention segments the delivery system into a mobile robotic platform that can be independently navigated to specific target locations within the body, separating the delivery function from systemic distribution. This allows localized therapeutic delivery to specific tissues or organs, minimizing adverse effects in other body regions while maintaining operational simplicity through automated navigation and positioning.
Solution Approach 2:
The mobile robotic platform serves as an intermediary carrier between the therapeutic agent and the target tissue. It mediates the delivery process by providing controlled transport to precise locations, enabling localized release while simplifying the overall administration process compared to multiple manual interventions required by traditional methods.
2Loss of substance
If traditional delivery means are used, then the therapeutic agent can be administered, but expensive drugs are wasted due to lack of targeted delivery
Solution Approach 1:
The invention applies local quality by concentrating the therapeutic agent within the mobile robotic platform and releasing it only at the specific target location. This localized delivery approach ensures that expensive drugs are not wasted through systemic distribution but are instead precisely delivered to where they are most needed, maximizing treatment efficacy while minimizing substance loss.
3Ease of operation
If traditional dosing regimens are used, then the patient must actively manage dosing instructions, but this creates significant burden especially for patients with limited ability
Solution Approach 1:
The mobile robotic platform performs self-service by autonomously navigating to target locations and delivering the therapeutic agent without requiring active patient management. The system handles dosing timing, location selection, and administration automatically, eliminating the burden of complex dosing regimens on patients while maintaining precise delivery control.
4Object-affected harmful factors
If frequent administration (injections or infusions) is used, then the therapeutic agent can be delivered, but this causes pain and discomfort to the patient
Solution Approach 1:
The invention applies preliminary action by loading the therapeutic agent into the mobile robotic platform before delivery, allowing for controlled release at the target location. This eliminates the need for frequent repeated injections or infusions, reducing patient discomfort while maintaining effective delivery through a single targeted intervention.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables targeted, controlled, and sustained release of therapeutic agents, minimizing adverse effects, conserving expensive drugs, and simplifying dosing regimens, thereby enhancing treatment efficacy and patient comfort.
Implementation Method 1
the biologic drug may be suspended in a hydrogel matrix
Implementation Method 2
the biologic drug may be suspended in an isotonic lyophilized polyplex
Data Source
AI summary
Provided herein are pharmaceutical formulations, methods of manufacturing thereof, and methods of treatment. The pharmaceutical formulations are adapted to serve as a pay load on or in a microbot, and comprise a tablet of a therapeutically effective dose of a pharmaceutical agent and have dimensions such that the tablet may fit on or in the microbot. The pharmaceutical formulation may be formed into, e.g., a cylinder or spheroid of 1 mm dimension, and the pharmaceutical agent may be a small molecule drug, a peptide, a peptoid, a biologic drug, cells, or any combination thereof. Thus, the pharmaceutical formulation of the present description offers delivery of targeted therapy at a locus in a subject, e.g., a tumor.