Ultrasound-Guided Microbubble Delivery via Real-Time Vessel Contour Tracking
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current ultrasound-guided drug-loaded microbubble delivery methods are inefficient due to manual operation, high costs of MRI guidance, and inaccuracy in drug delivery location, which affects the delivery efficiency and accuracy.
Innovation Solution
A method using an array transducer to emit ultrasonic signals for breaking drug-loaded microbubbles and obtaining ultrasound images, which identifies the contour of blood vessels and updates characteristic parameters in real time to improve delivery accuracy and efficiency.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If MRI guidance is used for UTMD, then temperature monitoring accuracy is improved, but equipment cost and operational complexity increase
Solution Approach 1:
The patent replaces MRI guidance with ultrasound imaging guidance, substituting a complex magnetic resonance system with a simpler ultrasound-based system. The ultrasound imaging device captures images of the microbubble distribution, and image processing algorithms automatically determine the breaking region, eliminating the need for complex MRI equipment and manual operation while maintaining sufficient monitoring accuracy.
2Device complexity
If manual operation is used for ultrasound imaging monitoring and microbubble breaking, then equipment cost is reduced, but delivery accuracy and efficiency deteriorate
Solution Approach 1:
The patent implements automatic image processing where the system autonomously analyzes ultrasound images, identifies microbubble distribution patterns, determines the optimal breaking region, and controls the ultrasonic signal transmission. This self-service approach eliminates manual operation, maintains high delivery accuracy through algorithm-based decision making, and improves efficiency by continuously optimizing the breaking parameters without human intervention.
Solution Approach 2:
The patent employs real-time feedback mechanisms where the system continuously monitors the microbubble distribution through ultrasound imaging, processes the images to update the breaking region parameters, and adjusts the ultrasonic signal accordingly. This closed-loop feedback system ensures continuous optimization of delivery accuracy and responsiveness throughout the entire treatment process.
3Ease of operation
If manual operation is used for microbubble breaking, then operational flexibility is maintained, but delivery time increases and efficiency decreases
Solution Approach 1:
The patent implements continuous automatic monitoring and adjustment throughout the entire microbubble breaking process. The system continuously acquires ultrasound images, processes them to track microbubble distribution changes, and dynamically adjusts breaking parameters without interruption. This continuous operation eliminates idle time between manual steps, maintains optimal conditions throughout the process, and significantly improves delivery efficiency while preserving operational flexibility through programmable control.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method enhances the accuracy and efficiency of drug delivery by continuously updating the breaking region parameters based on real-time blood vessel contours, reducing human error and shortening delivery time.
Implementation Method 1
emitting a first ultrasonic signal by utilizing an array transducer, to break a drug-loaded microbubble in a current breaking region
Implementation Method 2
an ultrasound contrast agent is utilized to induce a local part to generate a microflow and a shear force under a focused ultrasound action, which stimulates channels between pores of endothelial cell membranes and cells to be opened
Implementation Method 3
emitting a second ultrasonic signal by utilizing the array transducer, to obtain an ultrasound image
Data Source
AI summary
A method of delivery of an ultrasound-guided drug-loaded microbubble, an electronic device, and a computer-readable storage medium are provided. The method includes: emitting a first ultrasonic signal by utilizing an array transducer, to break a drug-loaded microbubble in a current breaking region; emitting a second ultrasonic signal by utilizing the array transducer, to obtain an ultrasound image; identifying a contour of a blood vessel of the breaking region based on the ultrasound image; and updating a characteristic parameter of the breaking region based on the contour of the blood vessel. According to the method, the breaking region is updated in real time based on the contour of the blood vessel, so that delivery accuracy of a drug-loaded microbubble is improved, and avoiding unnecessary tissue damage.