Microbubble-Enhanced Microbial Composition for Intestinal Engraftment
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Conventional intestinal flora transplantation methods face challenges such as slow engraftment, low colonization ratio, and a burdensome administration process, leading to limited retention and effectiveness of transplanted microorganisms.
Innovation Solution
A composition containing microorganisms derived from a living body, combined with nano-sized or smaller gas bubbles, which facilitates rapid and reliable engraftment by overcoming the mucous membrane barrier in the intestinal tract.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional intestinal flora transplantation methods are used, then microorganisms can be transplanted into the intestines, but the engraftment ratio is low (no more than 20% to 30%) and engraftment speed is slow
Solution Approach 1:
The patent introduces microbubbles as an intermediary substance between the transplanted microorganisms and the intestinal mucous membrane. The microbubbles facilitate the penetration of microorganisms through the mucous membrane barrier, significantly improving engraftment ratio to 80-90% and accelerating engraftment speed within hours rather than days.
Solution Approach 2:
The patent changes the physical state of the transplantation medium by incorporating microbubbles (gas phase) into the solvent. This parameter change from conventional liquid-only solutions to gas-liquid composite solutions enhances the ability of microorganisms to penetrate and engraft in the intestinal wall.
2Reliability
If conventional administration methods using large intestine endoscope are employed, then microorganisms can be delivered to the intestines, but a heavy burden is placed on the patient
Solution Approach 1:
The patent replaces complex, expensive, and invasive endoscopic equipment with simple, disposable microbubble solutions that can be administered through less invasive routes. This reduces the burden on patients while maintaining effective delivery of microorganisms to the target site.
3Ease of manufacture
If feces are dissolved in conventional solvents for transplantation, then a composition can be obtained, but the microorganisms are inhibited by the mucous membrane of the intestinal wall
Solution Approach 1:
The patent creates a composite transplantation medium consisting of solvent, microorganisms, and microbubbles. This composite material combines the benefits of liquid solvent for dissolution with gas bubbles for enhanced penetration capability, overcoming the limitation of conventional solvents that cannot help microorganisms penetrate the mucous membrane barrier.
Data Source
AI summary
Provided is a composition containing microorganisms derived from a living body with which more rapid and more reliable engraftment effect is achieved irrespective of the administration method and the administration route.A composition containing microorganisms derived from a living body, comprising (I) to (III) below is provided.(I) At least one or more types of microorganisms.(II) A solvent.(III) Nano-sized or smaller gas bubbles.