Microbubble Lyophilized Preparation Using Controlled PEG Folding

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Solution Overview

Problem

The storage stability of lyophilized compositions and the duration of microbubbles in suspensions for ultrasonic radiography are inadequate, as previously described compositions face issues with quality deterioration and high failure rates in production batches.

Innovation Solution

A microbubble lyophilized preparation for ultrasonic radiography is developed, comprising polyethylene glycol with a percentage of folded polymer chains less than 34%, along with a surfactant, fatty acid, and surface charge modifier, to enhance stability and microbubble performance.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Manufacturing precision

If polyethylene glycol with a percentage of folded polymer chain greater than 34% is used, then the lyophilized powder quality deteriorates and production batch failure rate increases, but the patent does not provide a solution for improving storage stability and microbubble duration

Engineering Contradiction:

Improvelyophilized powder qualityVSAvoidproduction batch acceptability

Core Design Contradiction:

Manufacturing precisionVSReliability

Solution Approach 1:

The patent applies parameter changes by specifying that polyethylene glycol should have a folded polymer chain percentage of 34% or less, and further preferably 30% or less. This parameter optimization resolves the manufacturing precision issue by establishing a clear quantitative criterion that prevents quality deterioration and production batch failures while enabling improved storage stability and microbubble duration.

Inventive Principle:

Principle #35Parameter changes

2Ease of manufacture

If conventional lyophilized composition is used, then the microbubble suspension can be prepared, but the storage stability is inadequate and microbubble duration is short

Engineering Contradiction:

Improvemicrobubble suspension preparationVSAvoidmicrobubble duration

Core Design Contradiction:

Ease of manufactureVSDuration of action of stationary object

Solution Approach 1:

The patent optimizes the folded polymer chain percentage parameter of polyethylene glycol to 34% or less, which fundamentally improves microbubble duration and storage stability while maintaining ease of manufacture. This parameter change enables the lyophilized composition to produce microbubbles that persist longer and maintain stability during storage.

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent creates a composite lyophilized composition combining polyethylene glycol with specific surfactants and additives that work synergistically to enhance microbubble stability and duration while maintaining ease of reconstitution and manufacture.

Inventive Principle:

Principle #40Composite materials

3Ease of manufacture

If conventional lyophilized composition is used, then the microbubble suspension can be prepared, but the particle size distribution is non-uniform and membrane strength is reduced

Engineering Contradiction:

Improvemicrobubble suspension preparationVSAvoidparticle size distribution uniformity

Core Design Contradiction:

Ease of manufactureVSManufacturing precision

Solution Approach 1:

The patent optimizes the folded polymer chain percentage parameter of polyethylene glycol to 34% or less, which directly improves particle size distribution uniformity and microbubble membrane strength while maintaining ease of manufacture. This parameter optimization ensures consistent microbubble formation with uniform size distribution.

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent develops a composite formulation combining polyethylene glycol with optimized surfactants and stabilizing agents that work together to produce uniform particle size distribution and enhance membrane strength, while maintaining ease of preparation through simple reconstitution procedures.

Inventive Principle:

Principle #40Composite materials

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The preparation achieves a more uniform particle size distribution and improved membrane strength of microbubbles, leading to a longer endurance time at high ultrasonic frequencies, thereby enhancing the stability and effectiveness of the contrast agent.

Implementation Method 1

the polyethylene glycol has a percentage of a folded polymer chain of less than 34%

Methodology Applied

Scientific EffectPolymer chain folding: Folding

Implementation Method 2

a microbubble lyophilized preparation for ultrasonic radiography

Methodology Applied

Scientific EffectLyophilization: Freeze Drying

Implementation Method 3

the lyophilized preparation comprises a surfactant, preferably an amphiphilic surfactant

Methodology Applied

Scientific EffectSurfactant stabilization: Surfactant

Data Source

PatentUS20250152754A1Microbubble lyophilized preparation for ultrasonic radiography, contrast agent, and preparation method

Publication Date: 2025.05.15 SHENZHEN XINQI PHARMACEUTICAL TECHNOLOGY CO LTD

AI summary

A microbubble lyophilized preparation for ultrasonic radiography relates to the field of contrast agents. The lyophilized preparation has polyethylene glycol and a surfactant. The percentage of the folded polymer chain of the polyethylene glycol is less than 34%. When the percentage of the folded polymer chain of the polyethylene glycol is less than 34%, while the redissolved microbubble solution has more uniform particle size distribution, the microbubbles show better film strength at the same ultrasonic frequency, and the endurance time is longer at high frequency.