Microbubble Radius Change Detection via Acoustic Emission
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Solution Overview
Problem
Current methods for estimating the oscillation state of microbubbles in focused ultrasound systems are limited in providing information about radius change (R(t)) over time, which is crucial for understanding the mechanical stress exerted on cells and tissues.
Innovation Solution
The system introduces microbubbles into a vessel and applies ultrasound waves to cause oscillation, generating acoustic waves that are received and processed to determine dynamic properties such as radius change, pressure, phase, frequency, and amplitude over time.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Loss of information
If current ultrasound methods are used to detect microbubble oscillation, then the oscillation state can be detected, but information about radius change over time is insufficient
Solution Approach 1:
The patent uses acoustic emission signals as an intermediary to indirectly measure microbubble radius changes. By detecting the acoustic waves emitted during microbubble oscillation and applying inverse modeling, the system reconstructs radius change information without directly measuring the microbubble dimensions, thus resolving the information loss problem.
Solution Approach 2:
The patent replaces direct mechanical measurement of microbubble radius with an acoustic field-based measurement system. By substituting mechanical probes with ultrasound transmission and acoustic emission detection, the system achieves non-invasive, high-precision measurement of microbubble dynamics including radius changes over time.
2Measurement precision
If acoustic emission detection is implemented to measure microbubble dynamics, then measurement precision is improved, but device complexity increases
Solution Approach 1:
The patent makes the ultrasound system multi-functional by enabling it to perform both therapeutic microbubble destruction and diagnostic radius change measurement using the same hardware components. The ultrasound transducer serves dual purposes: delivering therapeutic ultrasound and detecting acoustic emissions for measurement, thereby reducing overall device complexity.
Solution Approach 2:
The system uses the microbubble's own acoustic emission during oscillation as the measurement signal, eliminating the need for separate measurement probes or external measurement systems. The microbubble serves both as the therapeutic agent and the measurement target, providing self-contained measurement capability.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach allows for the accurate determination of microbubble dynamics, enabling a better understanding of the mechanical effects on tissues and improving the precision of microbubble-based therapeutic interventions.
Implementation Method 1
The ultrasound waves may cause the at least one microbubble to oscillate and emit at least one acoustic waves
Implementation Method 2
the at least one microbubble to oscillate and emit at least one acoustic waves
Implementation Method 3
providing ultrasound waves through an outer surface of the vessel and to at least a portion of the at least one microbubble
Data Source
AI summary
Systems and methods for determining microbubble dynamics. The method may comprise introducing at least one microbubble into a vessel. The method may also comprise providing ultrasound waves through an outer surface of the vessel and to at least a portion of the at least one microbubble, wherein the ultrasound waves cause the at least one microbubble to oscillate and emit acoustic waves. The method may further comprise receiving, via at least one receiver, the acoustic waves and generating acoustic emission data based on the acoustic waves. The method may further comprise determining, based at least in part on the acoustic emission data, an acoustic emission frequency of the at least one microbubble. The method may also comprise determining, based at least in part on the acoustic emission frequency, at least one dynamic property of the at least one microbubble.