Microchannel Test Apparatus for Uniform Fluid Distribution

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Solution Overview

Problem

In microchannel devices with branching channels, differences in fluid head between channels can cause uneven flow of test solutions, leading to incorrect results in sensitivity tests, such as those for bacteria antimicrobial sensitivity.

Innovation Solution

A test apparatus and method that includes a pressure application unit to inject test solutions into microchannels, an opening and closing unit to control fluid flow, and a controller to manage pressure and opening/closing operations, ensuring even distribution and collection of test solutions, thereby preventing flow discrepancies between channels.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Productivity

If air pressure is applied to inject test solution into branching microchannels from a single introduction port, then the test solution can be quickly and reliably filled into the microchannels, but differences in fluid head between channels cause uneven flow distribution and solution flow in the reaction portion

Engineering Contradiction:
Improvefilling speedVSAvoidflow distribution uniformity
Core Design Contradiction:
ProductivityVSManufacturing precision

Solution Approach 1:

The invention introduces collection portions at the ends of each branch channel to segment the fluid system. Each collection portion independently collects excess test solution from its corresponding branch channel, preventing inter-channel flow interference and ensuring uniform flow distribution while maintaining rapid filling capability through the single introduction port.

Inventive Principle:
Principle #1Segmentation

2Device complexity

If a single introduction port is used to inject test solution into multiple branch channels, then the device structure is simplified, but fluid head differences between channels cause flow variation and incorrect test results

Engineering Contradiction:
Improvenumber of introduction portsVSAvoidtest result accuracy
Core Design Contradiction:
Device complexityVSReliability

Solution Approach 1:

Collection portions are added at the ends of each branch channel to segment the fluid system. Each collection portion independently collects excess test solution from its corresponding branch channel, preventing inter-channel flow interference and ensuring uniform flow distribution while maintaining rapid filling capability through the single introduction port.

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The collection portions act as intermediary elements between the single introduction port and the multiple branch channels. They serve as buffer zones that absorb fluid head differences and prevent backflow or cross-contamination between channels, thereby maintaining test result accuracy while using a simplified single-port structure.

Inventive Principle:
Principle #24Intermediary (Mediator)

3Loss of substance

If air pressure is applied to collect test solution in collection portions, then excess solution is removed from branch channels, but the system requires additional control mechanisms for opening and closing

Engineering Contradiction:
Improveexcess solution removalVSAvoidcontrol mechanism complexity
Core Design Contradiction:
Loss of substanceVSDevice complexity

Solution Approach 1:

The second openings in the collection portions are designed to be dynamically controllable, switching between open and closed states. During injection, they remain closed to contain pressure; during collection, they open to allow excess solution to be removed by air pressure. This dynamic control enables efficient solution management without requiring complex continuous control systems.

Inventive Principle:
Principle #15Dynamics

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This approach allows for accurate observation of test results by ensuring consistent test solution distribution across all microchannels, suppressing flow differences and maintaining solution integrity within the microchannel device.

Implementation Method 1

a pressure application unit that is connected to the first opening and applies an air pressure to inject the test solution into the microchannels

Methodology Applied
Scientific EffectAir pressure: Pressure Increase

Implementation Method 2

the controller controls the opening and closing unit to open the second opening after the test solution is injected into the microchannels and controls the pressure application unit to apply an air pressure to collect in the collection portion, the test solution in each of the branch channels

Methodology Applied
Scientific EffectAir pressure: Pressure Increase

Data Source

PatentUS11992841B2Test apparatus, injection method, and microchannel device
Publication Date: 2024.05.28 SHIMADZU CORP
  • US11992841B2 patent drawing
  • US11992841B2 patent drawing
  • US11992841B2 patent drawing

AI summary

A test apparatus for a test using a test solution containing a sample with the use of a microchannel device is provided. The test apparatus includes a pressure application unit that is connected to a first opening and applies an air pressure to inject the test solution into a microchannel, an opening and closing unit that switches between opening and closing of a second opening, and a controller that controls the pressure application unit and the opening and closing unit. The controller controls the opening and closing unit to close the second opening, controls the pressure application unit to inject the test solution into the microchannel, controls the opening and closing unit to open the second opening after the test solution is injected into the microchannel, and controls the pressure application unit to apply an air pressure to collect in a collection portion, the test solution in a branch channel.