Microchip Electrophoresis Device with Standard Sample Verification
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Solution Overview
Problem
In microchip electrophoresis devices, deteriorated microchip performance or errors in the separation buffer can lead to incorrect analysis data, resulting in wasted time and samples.
Innovation Solution
A microchip electrophoresis device with a controller that performs electrophoresis analysis of a standard sample on each microchip before analyzing a sample, comparing the acquired data with stored standard data to determine if the microchip is suitable for analysis.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Speed
If electrophoresis analysis is performed using a microchip without prior verification, then analysis speed is improved, but measurement precision deteriorates due to undetected microchip performance degradation or buffer errors
Solution Approach 1:
The system performs preliminary verification by analyzing a standard sample on each microchip before analyzing the actual test sample. This preliminary action detects microchip performance degradation or buffer errors in advance, ensuring that only properly functioning microchips are used for the main analysis, thus maintaining both speed and precision.
Solution Approach 2:
The system implements a feedback mechanism where the analysis results of the standard sample are automatically evaluated, and based on this feedback, the suitability of the microchip for analyzing the test sample is determined. This closed-loop feedback ensures that only microchips meeting quality criteria are used, preventing inaccurate results while maintaining efficient workflow.
2Productivity
If electrophoresis analysis is performed without verifying microchip suitability, then productivity is improved, but reliability deteriorates due to incorrect analysis data
Solution Approach 1:
The system performs preliminary verification by analyzing a standard sample on each microchip before analyzing the actual test sample. This preliminary action detects microchip performance degradation or buffer errors in advance, ensuring that only properly functioning microchips are used for the main analysis, thus maintaining both speed and precision.
Solution Approach 2:
The system implements a feedback mechanism where the analysis results of the standard sample are automatically evaluated, and based on this feedback, the suitability of the microchip for analyzing the test sample is determined. This closed-loop feedback ensures that only microchips meeting quality criteria are used, preventing inaccurate results while maintaining efficient workflow.
3Measurement precision
If standard sample analysis is performed on each microchip before sample analysis, then measurement precision is improved, but loss of time increases due to additional verification steps
Solution Approach 1:
The system performs analysis of a standard sample on each microchip before analyzing the actual test sample. By using a standardized verification process with predetermined evaluation criteria, the system efficiently checks microchip suitability without excessive time investment, achieving the right balance between verification thoroughness and time efficiency.
4Reliability
If standard sample analysis is performed on each microchip before sample analysis, then reliability is improved, but loss of substance increases due to additional sample consumption
Solution Approach 1:
The system extracts a small portion of the test sample to create a standard sample for verification purposes. By using only a portion of the sample rather than the entire sample, the system performs necessary verification while minimizing sample consumption and waste.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Prevents electrophoresis analysis from being performed using unsuitable microchips, thereby ensuring accurate analysis data and reducing waste by identifying performance issues or buffer errors before sample analysis.
Implementation Method 1
a voltage application device that applies a voltage to the flow path in the microchip
Data Source
AI summary
A sample setting section in which at least one sample to be subjected to electrophoresis analysis and at least one standard sample are set, and a controller. The controller includes a standard data storage memory that stores standard data obtained by performing electrophoresis analysis of a standard sample under a predetermined condition, and a chip determination part configured to perform electrophoresis analysis of the standard sample under the predetermined condition using each of the at least one microchip before electrophoresis analysis of the sample set in the sample setting section is performed to acquire analysis data on the standard sample by the detector, and to perform a chip determination as to whether a state of each of the at least one microchip is suitable for performing electrophoresis analysis by comparing the acquired analysis data with the standard data on the standard sample.