Micro-device Disease Detection Apparatus
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Solution Overview
Problem
Current disease diagnosis technologies are inadequate for early and accurate detection of serious diseases like cancer, as they are often invasive, costly, and lack sensitivity and specificity, particularly in remote areas, and existing nano-technologies face challenges with complex sample preparation and subjective diagnosis methods.
Innovation Solution
Development of advanced micro-devices integrated with disease detection apparatus using state-of-the-art fabrication technologies to measure microscopic properties of biological samples, enabling sensitive, specific, and rapid disease detection at reduced costs and invasiveness.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If conventional imaging technologies (x-ray, CT scan, NMR) are used for disease diagnosis, then various degrees of usefulness are provided, but accurate and early stage detection is not achieved
Solution Approach 1:
The patent segments the detection function by moving from macroscopic imaging to microscopic analysis. Instead of using whole-body imaging, the system analyzes individual cells, molecules, or tissue sections at the microscopic level, enabling earlier detection of disease markers before they become visible through conventional imaging.
Solution Approach 2:
The patent replaces conventional mechanical imaging systems (x-ray, CT, NMR) with microscopic analysis systems that directly observe and measure biological structures at the cellular and molecular level. This substitution enables detection of disease markers that are invisible to macroscopic imaging but detectable through microscopic examination.
2Reliability
If existing diagnosis techniques are used, then disease detection is possible, but invasive procedures and high costs are required
Solution Approach 1:
The patent uses intermediary substances or markers that can be detected microscopically without requiring invasive procedures. These intermediaries (such as molecular markers, cellular components, or tissue markers) can be analyzed from minimally invasive samples like blood, urine, or saliva, maintaining diagnosis reliability while reducing patient harm.
Solution Approach 2:
The patent substitutes invasive mechanical biopsy procedures with microscopic analysis of minimally invasive samples. Instead of requiring tissue removal through surgery or advanced imaging, the system uses microscopic examination of readily available biological samples to achieve reliable diagnosis.
3Measurement precision
If nano-technologies are used for disease detection, then sensitivity may be improved, but complex sample preparation and subjective diagnosis methods are required
Solution Approach 1:
The patent extracts and simplifies the sample preparation steps by directly analyzing minimally processed biological samples at the microscopic level. Instead of requiring complex nano-scale sample preparation, the system can work with readily available samples (blood, urine, saliva) that need only basic processing, reducing overall system complexity while maintaining sensitivity.
Solution Approach 2:
The patent uses microscopic imaging and analysis as a direct copy or representation of the biological state, eliminating the need for complex nano-scale manipulations. The microscopic view provides a direct copy of cellular and molecular structures that can be analyzed without requiring complex sample preparation procedures.
4Ease of operation
If visual and color change methods are used for diagnosis, then simplicity is maintained, but resolution and objectivity are limited
Solution Approach 1:
The patent substitutes subjective visual and color change assessment with objective microscopic analysis. Instead of relying on human eyes to interpret visual changes, the system uses microscopic imaging and measurement techniques that provide objective, quantifiable data about cellular and molecular structures, significantly improving resolution and diagnostic objectivity.
Data Source
AI summary
Among others, the present invention provides apparatus for detecting a disease, comprising a system delivery biological subject and a probing and detecting device, wherein the probing and detecting device includes a first micro-device and a first substrate supporting the first micro-device, the first micro-device contacts a biologic material to be detected and is capable of measuring at the microscopic level an electric, magnetic, electromagnetic, thermal, optical, acoustical, biological, chemical, physical, or mechanical property of the biologic material.