Micro-device Disease Detection Apparatus for Early Diagnosis
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current disease diagnosis technologies are inadequate for early and accurate detection of serious diseases like cancer, as they are invasive, costly, and lack sensitivity and specificity, particularly in remote areas, and existing nano-technologies face challenges with complex sample preparation and subjective data interpretation.
Innovation Solution
Development of advanced micro-devices integrated with disease detection apparatus using state-of-the-art fabrication technologies to measure microscopic properties of biological samples, enabling sensitive, specific, and cost-effective early-stage disease detection.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If current imaging technologies (x-ray, CT scan, NMR) are used for disease diagnosis, then various degrees of usefulness in disease diagnosis is provided, but accurate, safe, and cost-effective diagnosis of serious diseases like cancer at early stage cannot be achieved
Solution Approach 1:
The patent divides the diagnosis system into multiple independent micro-devices, each capable of performing specific detection functions. These micro-devices can be individually optimized for particular biological targets or detection modes, allowing the system to achieve high measurement precision for early-stage disease detection while maintaining manageable complexity through modular architecture.
Solution Approach 2:
The patent transitions from macroscopic imaging to microscopic detection by operating at the cellular and molecular level. This dimensional shift enables detection of disease markers before they become visible through conventional imaging, significantly improving early-stage diagnosis accuracy without requiring complex multi-modality imaging systems.
2Measurement precision
If existing nano-technologies are used for disease detection, then some sensing capabilities are provided, but complicated sample preparation procedures and difficulty in data interpretation occur
Solution Approach 1:
The micro-devices are designed to perform multiple functions including sample processing, detection, and data analysis autonomously. The system can automatically prepare samples, perform measurements, and interpret data without requiring complex manual procedures, thereby maintaining high sensitivity while significantly simplifying operation for users in remote or resource-limited settings.
Solution Approach 2:
The patent develops universal micro-device platforms that can detect multiple disease markers and perform various analysis functions through a single integrated system. This multi-functionality eliminates the need for multiple specialized devices and complex sample preparation protocols, making the system both sensitive and easy to operate across different diagnostic applications.
3Quantity of substance
If conventional diagnosis apparatus are used, then macroscopic data can be obtained, but invasive procedures and high costs are incurred
Solution Approach 1:
The patent detects disease markers at the microscopic level (cells, molecules) rather than requiring macroscopic tissue samples. This enables diagnosis using minimal biological material such as blood, urine, or saliva, eliminating the need for invasive biopsies while maintaining diagnostic accuracy through highly sensitive detection of individual cellular or molecular features.
4Adaptability or versatility
If existing detection systems are used, then basic sensing is provided, but limited functions and lack of specificity occur
Solution Approach 1:
The system employs multiple specialized micro-devices, each optimized for detecting specific biological markers or disease-related parameters. This segmentation allows the system to maintain high specificity for particular disease markers while achieving versatility through the combination of multiple devices that can detect different markers, enabling comprehensive disease screening and diagnosis.
Data Source
AI summary
The present invention provides, among others, apparatus for detecting a disease, comprising a system delivery biological subject and a probing and detecting device, wherein the probing and detecting device includes a first micro-device and a first substrate supporting the first micro-device, the first micro-device contacts a biologic material to be detected and is capable of measuring at the microscopic level an electric, magnetic, electromagnetic, thermal, optical, acoustical, biological, chemical, physical, or mechanical property of the biologic material.