Microdroplet API Dosing With Imaging Feedback for Repeatable Dosage
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Solution Overview
Problem
Existing methods for delivering active pharmaceutical ingredients, such as cannabinoids, in food products suffer from inaccuracies and inconsistencies in dosage, leading to variable pharmaceutical effects across different regions of the same product.
Innovation Solution
A dosing system that includes a dosing head to deliver microdroplets of active pharmaceutical ingredients to a substrate, accompanied by an imaging system to monitor and adjust the delivery, ensuring precise and consistent dosing through feedback mechanisms.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If conventional dosage techniques are used, then the dosing process is simple, but dosage accuracy and repeatability are poor
Solution Approach 1:
The patent implements feedback control by capturing images of delivered microdroplets, determining their volumes, comparing actual volumes to target volumes, and adjusting dosing parameters in real-time to correct deviations and achieve precise dosage accuracy
Solution Approach 2:
The patent replaces conventional mechanical dosing methods with a system that uses imaging technology and computational analysis to measure and control microdroplet volumes, substituting optical and digital systems for traditional mechanical dosage control
2Manufacturing precision
If batch-produced food products are used, then production efficiency is high, but dosage consistency across different regions is poor
Solution Approach 1:
The patent segments the dosing process into discrete microdroplet deliveries to specific locations on the substrate, with each microdroplet's volume and placement independently controlled and verified through imaging, ensuring consistent dosage across different regions while maintaining production efficiency
Solution Approach 2:
The patent uses a liquid handling system with dosing heads that deliver precise volumes of liquid through controlled fluid delivery mechanisms, enabling accurate and repeatable dosage application across multiple substrates in a production environment
3Measurement precision
If microdroplet delivery with imaging verification is implemented, then dosage precision is improved, but system complexity and measurement requirements increase
Solution Approach 1:
The system performs self-verification by automatically capturing images of delivered microdroplets, calculating their volumes based on image analysis, and using this measurement data to adjust subsequent dosing operations, creating a self-correcting measurement and control system
Data Source
AI summary
This present disclosure provides reliable methods and apparatus for delivering microdroplets containing an active pharmaceutical ingredient (API) to underlying substrates. A control system is provided to ensure that the API dosage is both accurate and repeatable.