Micro-fibrillated Cellulose Disintegrator for High-Concentration Tablets
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Solution Overview
Problem
Existing disintegrating tablets do not effectively incorporate high concentrations of active ingredients such as medicinal, nutritional, and food components, and lack efficient disintegration properties.
Innovation Solution
A composition comprising micro-fibrillated cellulose as the sole disintegrator component, with an active ingredient concentration of 80-90 wt%, achieving excellent tablet hardness and disintegrability without additional disintegrators.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Strength
If multiple disintegrators are used in addition to micro-fibrillated cellulose, then tablet hardness increases due to synergistic effect, but disintegration time in water becomes shorter and formulation complexity increases
Solution Approach 1:
The invention extracts and isolates the disintegrator function to micro-fibrillated cellulose alone, removing other disintegrators from the formulation. This simplification maintains tablet hardness through optimized micro-fibrillated cellulose content (1-20 wt%) while achieving rapid disintegration, thereby resolving the contradiction between formulation complexity and performance.
Solution Approach 2:
The invention changes the parameter of disintegrator composition from multiple components to a single component (micro-fibrillated cellulose), and optimizes its concentration parameter (1-20 wt%) to achieve both adequate tablet hardness and rapid disintegration, eliminating the need for synergistic combinations of multiple disintegrators.
2Quantity of substance
If micro-fibrillated cellulose is used as the sole disintegrator, then active ingredient concentration can be increased to 80-90 wt%, but tablet formulation requires precise optimization
Solution Approach 1:
The invention changes the formulation parameter by using micro-fibrillated cellulose at optimized concentrations (1-20 wt%) as the sole disintegrator, enabling active ingredient concentration to reach 80-90 wt%. The specific parameter optimization provides a clear numerical range that balances high active ingredient content with adequate tablet hardness and disintegration performance.
3Device complexity
If conventional cellulose is used as disintegrator, then formulation is simple, but disintegration performance and water-retaining property are insufficient
Solution Approach 1:
The invention changes the physical parameter of cellulose from conventional forms to micro-fibrillated form with fiber diameter of a few nm to a few μm. This parameter change dramatically improves surface area, hydrophilic property, and three-dimensional network formation, achieving excellent disintegration performance and water-retaining properties while maintaining formulation simplicity through single-component use.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The use of micro-fibrillated cellulose allows for high active ingredient concentration and rapid disintegration in water, with tablet hardness ranging from 10 to 200 N and disintegration time of 6 minutes or less, enhancing the production and performance of disintegrating tablets.
Implementation Method 1
a surface area has been increased, hydrophilic property that is the original characteristics of cellulose has been significantly strengthened, and a three-dimensional network has been formed
Implementation Method 2
hydrophilic property that is the original characteristics of cellulose has been significantly strengthened
Implementation Method 3
a three-dimensional network has been formed, without deteriorating basic properties such as physical and chemical stabilities
Data Source
AI summary
The purpose of the present invention is to provide various kinds of disintegrating tablets having various purposes and applications, such as for pharmaceuticals Chinese medicine and various kinds of foods and comprising various kinds of active ingredients such as the medicinal or nutritional ingredient, the supplement and the food component at a high concentration; and a composition for the disintegrating tablets. The present invention relates to a composition for a disintegrating tablet, comprising a disintegrator component consisting of only micro-fibrillated cellulose, and an active ingredient; and a disintegrating tablet for pharmaceuticals or foods, comprising the composition.