Microfluidic Chip Negative Pressure Generation Unit
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Solution Overview
Problem
Current microfluidic analysis chips lack the capability to effectively adjust the movement of samples or reagents through a negative pressure generation unit, limiting their control and efficiency in biochemical analysis.
Innovation Solution
A microfluidic analysis chip design that includes a main channel microtube, a chip housing with a negative pressure generation unit, and a sealing film, where the negative pressure generation unit consists of a pressed and pushed unit made of elastic material, and a fine needle for piercing the sealing film, allowing for controlled movement of samples and reagents through pressure adjustments.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If a negative pressure generation unit is added to control sample movement, then the control precision and efficiency are improved, but the device complexity increases
Solution Approach 1:
The pressed unit is made of elastic material that automatically restores its shape after being pressed, generating negative pressure without requiring additional control mechanisms. The elastic material stores mechanical energy during pressing and releases it during restoration, creating a self-contained negative pressure generation system that reduces overall device complexity while maintaining control precision
Solution Approach 2:
A sealing film is introduced as an intermediary component between the pressed unit and the external environment. This sealing film ensures that negative pressure is generated effectively within the microtube while isolating the elastic material from direct contact with samples or reagents, thus maintaining control precision without compromising system simplicity
2Ease of operation
If the negative pressure generation unit uses elastic material for the pressed unit, then the ease of operation is improved, but the manufacturing precision requirements increase
Solution Approach 1:
The elastic material's physical parameters (such as elasticity modulus, thickness, and geometry) are optimized to achieve the desired negative pressure generation. By carefully selecting and tuning these parameters, the system achieves easy operation through simple pressing actions while managing manufacturing precision requirements through standardized material specifications and design tolerances
Data Source
AI summary
The present specification discloses a microfluidic analysis chip capable of adjusting movement of a specimen or a reagent by a negative pressure generation unit. A microfluidic analysis chip according to the present specification may comprise: a microtube for a main channel, which provides a space in which a specimen input through a specimen inlet formed at one end thereof reacts with a regent while the specimen moves to the other end thereof; a chip housing surrounding the microtube for the main channel; and a negative pressure generation unit which is positioned in the chip housing and connected to the microtube, so as to affect an internal pressure of the microtube for the main channel.