Microfluidic Chip Plate With Identical Elution Ducts
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Solution Overview
Problem
Existing microfluidic chip plates for lysing micro-organisms often produce unequal and unreliable results due to differences in elution duct lengths, leading to false-negative test results.
Innovation Solution
A compact microfluidic plate design featuring identical fluidic networks and elution ducts for each chip, ensuring consistent DNA collection and reducing the likelihood of false-negative results.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If chips are arranged in a plate to improve laboratory efficiency, then productivity increases, but manufacturing precision deteriorates due to unequal elution duct lengths causing false-negative results
Solution Approach 1:
The plate is divided into multiple identical chips, each with its own lysing chamber and fluidic network. By segmenting the system into replicate units with identical elution duct lengths, the patent ensures that each chip provides equivalent results while maintaining high productivity through parallel processing of multiple samples
Solution Approach 2:
The patent specifies precise geometric parameters for the elution ducts, including length, width, and curvature radius, to ensure identical flow characteristics across all chips. By controlling these parameters within tight tolerances, the patent eliminates variations in DNA elution efficiency that would otherwise lead to false-negative results
2Device complexity
If elution duct length varies across chips, then device complexity is reduced, but reliability deteriorates due to inconsistent DNA collection and false-negative tests
Solution Approach 1:
The patent employs identical fluidic network designs across all chips in the plate, ensuring homogeneous elution duct geometry, material composition, and surface properties. This homogeneity guarantees consistent DNA elution behavior across all chips, eliminating the reliability issues caused by manufacturing variations
3Quantity of substance
If DNA is transferred through elution ducts, then the function of DNA collection is achieved, but loss of substance occurs due to DNA clogging and sticking to duct walls
Solution Approach 1:
The patent optimizes the elution duct dimensions, including length, width, and curvature radius, to minimize DNA loss through clogging and adhesion. By carefully controlling these geometric parameters, the patent reduces the surface area available for DNA sticking while maintaining adequate flow characteristics
Data Source
Figure 1(I)~1(IV)
Figure 2
Figure 3~4
AI summary
The present invention relates to a plate (1) comprising at least two chips (10) designed for receiving a sample to be lysed, each chip (10) featuring a fluidic network comprising fluidic interfaces (11) which includes: - ports, including: - an elution port (23) linked to a lysing chamber, - a sample outlet port (22) configured for collecting a lysed sample - ducts, including an elution duct between the elution port (23) and the sample outlet port (22), for transferring a lysed sample from the lysing chamber; the chips (10) being aligned with an axis (10a) and regularly spaced apart so that the sample outlet port (22) of each chip (10) coincides with the axis (10a), and are spaced apart with a pitch, characterised in that the elution duct is identical for each chip (10) of the plate (1).