Microfluidic Chip for Two-Dimensional Protein Separation

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Solution Overview

Problem

Existing methods for two-dimensional protein separation, particularly those involving capillary electrophoresis, are slow and prone to heat dissipation issues when high voltage is applied, leading to low separation speed and difficulties in comparing results with classic 2D gel electrophoresis.

Innovation Solution

The method employs a chip-based capillary electrophoretic separation with a precolumn having a lipophilic stationary phase preceding an ion exchange column, allowing for faster separation and more precise protein analysis, using a chip with grooves for electrophoresis gel and a voltage source, and a precolumn with a lipophilic stationary phase connected to the ion exchange column.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Speed

If capillary electrophoresis is used for protein separation, then separation speed is improved, but heat dissipation problems occur when high voltage is applied

Engineering Contradiction:
Improveseparation speedVSAvoidheat dissipation problems
Core Design Contradiction:
SpeedVSObject-affected harmful factors

Solution Approach 1:

The patent replaces traditional mechanical cooling systems with a microfluidic chip-based electrophoresis system that inherently dissipates heat through its small channel dimensions and large surface-to-volume ratio, eliminating complex heat dissipation mechanisms while maintaining high separation speed

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The microfluidic chip uses thin film structures and small channel dimensions to maximize surface area for heat dissipation, allowing efficient thermal management without complex external cooling systems, thus resolving the heat dissipation problem while maintaining fast separation

Inventive Principle:
Principle #30Flexible shells and thin films

2Productivity

If conventional capillary electrophoresis is used, then separation can be performed, but the results are difficult to compare with classic 2D gel electrophoresis

Engineering Contradiction:
Improveseparation capabilityVSAvoidcomparability with classic methods
Core Design Contradiction:
ProductivityVSLoss of information

Solution Approach 1:

The microfluidic chip system is designed to provide separation results that are comparable across different platforms (chip-based, capillary, and gel electrophoresis), creating a universal system that maintains method comparability while enabling high-throughput automated analysis

Inventive Principle:
Principle #6Universality (Multi-functionality)

Solution Approach 2:

The patent optimizes electrophoresis parameters (voltage, buffer composition, channel dimensions) to produce separation patterns that correlate with classic 2D gel electrophoresis results, ensuring data comparability while achieving faster separation speeds and higher productivity

Inventive Principle:
Principle #35Parameter changes

3Measurement precision

If two-dimensional protein separation is performed using traditional methods, then comprehensive protein analysis is achieved, but the process takes too much time

Engineering Contradiction:
Improveprotein analysis comprehensivenessVSAvoidseparation time
Core Design Contradiction:
Measurement precisionVSLoss of time

Solution Approach 1:

The patent integrates multiple separation dimensions into a single microfluidic chip platform, segmenting the complex two-dimensional separation process into integrated on-chip modules that achieve comprehensive protein analysis in under three hours compared to traditional multi-step methods

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The invention merges ion-exchange chromatography and capillary electrophoresis into an integrated microfluidic system, combining first and second dimension separations in one continuous automated process, thereby achieving comprehensive 2D protein separation while reducing total analysis time to under three hours

Inventive Principle:
Principle #5Merging (Combining)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This approach significantly reduces the time required for two-dimensional protein separation to under three hours, enabling routine examinations and precise protein content determination, allowing for systematic study of protein composition changes in body fluids or under medication.

Implementation Method 1

separating the proteins according to their isoelectric point by ion-exchange chromatography using an ion-exchange column

Methodology Applied
Scientific EffectIon-exchange chromatography: Ion Exchange

Implementation Method 2

capillary electrophoretic separation of the fractional sample

Methodology Applied
Scientific EffectCapillary electrophoresis: Capillary Electrophoresis

Implementation Method 3

separation device for capillary electrophoretic separation of the fractional sample

Methodology Applied
Scientific EffectElectrophoresis: Electrophoresis

Implementation Method 4

a pre-column comprising a lipophilic stationary phase is placed upstream of the ion-exchange column

Methodology Applied
Scientific EffectHydrophobic interaction: Hydrophobe

Data Source

PatentEP3566045B1Method for two-dimensional protein separation and protein-separating device
Publication Date: 2020.09.09 TECH UNIV BRAUNSCHWEIG
  • EP3566045B1 patent drawingFigure 1
  • EP3566045B1 patent drawingFigure 2
  • EP3566045B1 patent drawingFigure 3

AI summary

The invention relates to a method for two-dimensional protein separation, having the following steps: (a) separating the proteins according to the isoelectric point thereof by ion exchange chromatography by means of an ion exchange column (12) such that a fraction collective (14) is obtained and (b) separating the fraction collective (14) by capillary electrophoresis, wherein (c) the separating by capillary electrophoresis is carried out by means of a chip (18).