Microfluidic Chip With Integrated Semiconductor For Rapid Multi-Analyte Detection
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Solution Overview
Problem
Traditional microfluidic chips require large sample volumes and long detection times, making them inefficient for simultaneous detection of multiple biomarkers or biological signals, which is a limitation in applications like early diagnosis and point-of-care medicine.
Innovation Solution
A microfluidic chip system integrating a semiconductor chip with a channel layer and electrode layers, allowing for the detection of multiple compounds, biomarkers, or biological signals simultaneously by controlling the flow of microdroplets through the channel layer, thereby reducing sample requirements and detection time.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If traditional microfluidic chip design is used, then detection of multiple biomarkers is possible, but sample volume requirement is large and detection time is long
Solution Approach 1:
The chip is divided into multiple independent detection regions, each containing a semiconductor chip for detecting different biomarkers. This segmentation allows parallel processing of multiple analytes simultaneously, improving detection throughput while reducing the total sample volume needed compared to sequential detection methods
Solution Approach 2:
The patent transitions from traditional planar microfluidic channels to a three-dimensional structure by stacking multiple detection regions vertically. This dimensional change enables multiple detection zones to occupy the same footprint area, allowing simultaneous detection of multiple biomarkers with reduced sample consumption and faster processing
2Loss of time
If traditional microfluidic chip design is used, then detection capability is provided, but detection time is long
Solution Approach 1:
The microdroplets are pre-formed and loaded into the channel layer before entering the detection regions. This preliminary preparation eliminates time-consuming sample introduction steps during detection, reducing overall detection time while maintaining measurement precision through controlled droplet delivery to each semiconductor chip
Solution Approach 2:
The channel layer continuously transports microdroplets through all detection regions in a single flow path, enabling simultaneous detection of multiple biomarkers without interrupting the analytical process. This continuous operation eliminates idle time between measurements and maintains consistent detection accuracy across all channels
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables few sample requirements and rapid detection of multiple analytes simultaneously, enhancing the efficiency and applicability of microfluidic technology in bioanalysis and diagnostics.
Implementation Method 1
The first component includes a first substrate, a first electrode layer, and a first dielectric layer, wherein the first electrode layer is located between the first substrate and the first dielectric layer
Data Source
AI summary
A microfluidic chip suitable for detecting a microdroplet includes a first component, a second component, a channel layer, and a semiconductor chip. The first component includes a first substrate, a first electrode layer, and a first dielectric layer, wherein the first electrode layer is located between the first substrate and the first dielectric layer. The second component is disposed opposite to the first component and includes a second substrate, a second electrode layer, and a second dielectric layer. The channel layer is located between the first component and the second component. The semiconductor chip is disposed at one side of the first substrate and is exposed to the channel layer to assist in treating or detecting a sample or microdroplet. The microdroplet in the sample entering the channel layer is reacted with the semiconductor chip, and thus the sample is detected.