Multi-Channel Microfluidic Blood Coagulation Chip with Layered Electrodes
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Solution Overview
Problem
Existing microfluidic blood coagulation detection chips face issues of electrode interference, large size, high cost, and low detection efficiency and accuracy due to the design of electrodes on a single layer and large chip dimensions.
Innovation Solution
A multi-channel microfluidic blood coagulation detection chip with a three-layer structure, featuring upper-layer and lower-layer electrodes separated by a gap, and a specific channel design for sample flow, allowing for independent detection chambers and reduced electrode interference, enabling simultaneous detection of multiple coagulation indexes.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Device complexity
If multiple detection chambers share the same reference electrode on a single layer, then device complexity is reduced, but electrode interference increases and measurement precision deteriorates
Solution Approach 1:
The chip is divided into multiple independent detection chambers, each with its own working electrode and reference electrode. This segmentation eliminates electrode interference between channels while maintaining relatively simple device structure through modular design.
Solution Approach 2:
The patent transitions from a single-layer electrode design to a multi-layer structure where electrodes are distributed across different vertical levels. This dimensional change allows multiple detection chambers to have independent electrodes without increasing planar complexity, resolving the contradiction between device simplicity and measurement precision.
2Productivity
If chip size is increased to accommodate multiple independent detection chambers, then detection throughput increases, but device size and production cost increase
Solution Approach 1:
Multiple detection chambers are nested within a compact chip structure with shared microfluidic channels and integrated electrode arrays. This nesting approach allows high detection throughput while minimizing chip volume and reducing production costs through efficient space utilization.
Solution Approach 2:
The chip design incorporates shared microfluidic channels and common structural elements that serve multiple detection chambers simultaneously. This multi-functionality increases detection throughput without proportionally increasing chip size or production cost.
3Ease of manufacture
If electrodes are designed on a single layer, then manufacturing process is simplified, but electrode interference increases and detection accuracy deteriorates
Solution Approach 1:
The patent implements a multi-layer electrode architecture where working electrodes and reference electrodes are positioned on different vertical layers. This dimensional separation eliminates electrochemical interference while maintaining manufacturing feasibility through standardized multi-layer fabrication processes.
Solution Approach 2:
Each detection chamber is designed with localized electrode pairs positioned in specific spatial relationships optimized for their function. This local quality optimization ensures high detection accuracy in each chamber while the overall multi-layer structure maintains manufacturing simplicity through repetition of standardized electrode patterns.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The chip achieves high detection accuracy, efficiency, and reduced size, lowering production costs while facilitating quick and simultaneous detection of multiple coagulation indexes with minimal resource consumption.
Implementation Method 1
a microfluidic channel, and the microfluidic channel communicates with the detection chambers
Implementation Method 2
The electrodes include upper-layer electrodes and lower-layer electrodes... facilitating quick and simultaneous detection of multiple coagulation indexes
Data Source
AI summary
A multi-channel microfluidic blood coagulation detection chip includes a chip body. The chip body includes a lower-layer chip, a middle-layer chip, and an upper-layer chip in sequence from bottom to top. The lower-layer chip, the middle-layer chip, and the upper-layer chip cooperate with each other to define a closed microfluidic channel and a plurality of mutually-independent detection chambers. The upper-layer chip is provided with a sample loading hole, and the sample loading hole communicates with the detection chambers through the microfluidic channel. The chip body further includes electrodes. The electrodes include upper-layer electrodes and lower-layer electrodes, the upper-layer electrodes are disposed on a back surface of the upper-layer chip, the lower-layer electrodes are disposed on a front surface of the lower-layer chip, and a gap is provided between the upper-layer electrodes and the lower-layer electrodes.